{"id":"W4414287732","doi":"10.14740/wjon2640","title":"Targeting the Phosphoinositide 3-Kinase/Protein Kinase B Pathway Suppresses Y-Box Binding Protein 1 Expression and Inhibits Colorectal Cancer Progression","year":2025,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Government of Jiangsu Province; Jiangsu University","keywords":"Colorectal cancer; Phosphoinositide 3-kinase; Kinase; PI3K/AKT/mTOR pathway; Signal transduction; Protein kinase A; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825904,0.0003760468,0.0004564988,0.0004167594,0.0001773094,0.0002380192,0.0002101608,0.0001857303,0.001522234],"category_scores_gemma":[0.0001102631,0.0001168271,0.0002711347,0.0002950494,0.0002147759,0.0001301131,0.0001572876,0.0006248388,0.0003796993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003063701,"about_ca_system_score_gemma":0.0003871171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005968715,"about_ca_topic_score_gemma":0.001610381,"domain_scores_codex":[0.9998744,0.00001524314,0.00001037252,0.00002361003,0.00003710761,0.00003937815],"domain_scores_gemma":[0.9999356,0.00000808518,0.00002131818,0.000006284452,0.000006861228,0.0000217026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001022852,0.000318984,0.0009539783,0.0003544552,0.00004788953,0.00006531717,0.00002967512,0.0004174803,0.9818315,0.0001739895,0.000888208,0.01389571],"study_design_scores_gemma":[0.0003469533,0.00364806,0.02368717,0.00003465219,0.0001649596,0.0005411304,0.00008041706,0.005112761,0.9530658,0.0001181077,0.01318181,0.00001814294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871345,0.007078835,0.001902271,0.0002093386,0.00008030429,0.00007487253,0.00100934,0.0004339561,0.002076576],"genre_scores_gemma":[0.9922863,0.00300074,0.001411906,0.00009466871,0.00001402968,0.00009631059,0.001377274,0.00003052458,0.001688216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522234,"threshold_uncertainty_score":0.005092382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0091616515756994,"score_gpt":0.3026456069347914,"score_spread":0.293483955359092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}