{"id":"W4414292494","doi":"10.1111/dom.70135","title":"Coated glucose microbeads stimulate enteric hormone release and improve glucose tolerance in Phase 1 and 2 clinical trials","year":2025,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Heart and Stroke Foundation; University of Toronto","funders":"","keywords":"Enteroendocrine cell; Clinical trial; Endogeny; Adverse effect; Glucagon-like peptide-1; Endocrine system; Hormone; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002510865,0.001492907,0.001491079,0.0004127078,0.000303701,0.001121088,0.0007440697,0.001837151,0.004860159],"category_scores_gemma":[0.001564174,0.0004047038,0.001503185,0.0004703565,0.0006284884,0.0008461903,0.0002742904,0.002325574,0.0007635746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000794079,"about_ca_system_score_gemma":0.0009563003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004317939,"about_ca_topic_score_gemma":0.001191868,"domain_scores_codex":[0.9992084,0.0003625395,0.00005160207,0.0001045126,0.0001277018,0.0001453254],"domain_scores_gemma":[0.99935,0.0001351277,0.0002106433,0.00005117661,0.00008983642,0.0001631746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6386594,0.05173169,0.003507843,0.004099851,0.003040967,0.0002907747,0.0002343308,0.002142988,0.0624048,0.0007618237,0.01536368,0.2177619],"study_design_scores_gemma":[0.6087297,0.3654702,0.007164588,0.0002058455,0.0007813321,0.0001904648,0.00004259855,0.000904157,0.008228601,0.0002851996,0.007954579,0.00004282604],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508585,0.02245655,0.003086002,0.002212266,0.0008796909,0.0108738,0.003188984,0.0004861319,0.005957974],"genre_scores_gemma":[0.9553555,0.01336028,0.006742026,0.00395168,0.0007164233,0.009631224,0.004605323,0.0001103938,0.005527098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004860159,"threshold_uncertainty_score":0.01625884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251802642745963,"score_gpt":0.3321211460644948,"score_spread":0.3096031196370351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}