{"id":"W4414292680","doi":"10.1111/acel.70234","title":"Sex‐ and <scp>APOE</scp> Genotype–Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme <scp>LPCAT2</scp>","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; National Health Research Institutes; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Mendelian randomization; Disease; Apolipoprotein E; Genetic predisposition; Cognitive decline; Biomarker; Genotype; Chronic pain; Transcriptome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009143,0.0003844656,0.0001758607,0.0004177759,0.0002139616,0.0004439244,0.0001670907,0.0003333366,0.002538912],"category_scores_gemma":[0.0003546172,0.0001076054,0.0004212927,0.0003043834,0.0002495878,0.0001521219,0.0002088192,0.0004550402,0.0002964284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000172779,"about_ca_system_score_gemma":0.0002379098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002196203,"about_ca_topic_score_gemma":0.003187084,"domain_scores_codex":[0.9998784,0.0000184778,0.00001111257,0.0000453783,0.00002436538,0.00002227057],"domain_scores_gemma":[0.9997922,0.00002980778,0.00009161937,0.00002500407,0.00003002733,0.00003132181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006207551,0.0002604561,0.3919548,0.0001994257,0.0006680706,0.00247065,0.0003441779,0.000334543,0.5739689,0.001087456,0.001058717,0.02144517],"study_design_scores_gemma":[0.0000731035,0.0003896306,0.96495,0.00002459881,0.0002648895,0.002891224,0.0001641966,0.001205375,0.02700881,0.0008548484,0.002150773,0.00002276651],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967548,0.0005211583,0.0009168477,0.0001526717,0.00002497637,0.000009919974,0.0008187043,0.00002118809,0.0007796992],"genre_scores_gemma":[0.9970879,0.000247525,0.0004857992,0.00009785289,0.00001912434,0.00001771665,0.0006093997,0.00001600065,0.001418775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002538912,"threshold_uncertainty_score":0.008493543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009190733831052086,"score_gpt":0.2384143300954014,"score_spread":0.2292235962643493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}