{"id":"W4414292680","doi":"10.1111/acel.70234","title":"Sex‐ and <scp>APOE</scp> Genotype–Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme <scp>LPCAT2</scp>","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; National Health Research Institutes; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Mendelian randomization; Disease; Apolipoprotein E; Genetic predisposition; Cognitive decline; Biomarker; Genotype; Chronic pain; Transcriptome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00232306,0.0003984208,0.0005471954,0.0001199041,0.0003567244,0.00008844818,0.0001856569,0.0001970464,0.00001820103],"category_scores_gemma":[0.0007832206,0.0002821827,0.0001021695,0.000266584,0.0001551701,0.00008512638,0.0001950676,0.0004758042,0.00003653082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005125537,"about_ca_system_score_gemma":0.0001016813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000931412,"about_ca_topic_score_gemma":0.00009591413,"domain_scores_codex":[0.9973313,0.000599871,0.0003794966,0.000736051,0.0003713901,0.0005818638],"domain_scores_gemma":[0.9967483,0.002043134,0.0001799501,0.0006633344,0.00008463296,0.0002806865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007844628,0.0030981,0.5041317,0.0009648634,0.007601532,0.0003908723,0.02048199,0.00003226821,0.2082757,0.001082211,0.1610414,0.09282091],"study_design_scores_gemma":[0.01703801,0.000851617,0.1581917,0.000339255,0.009428733,0.000080991,0.009836857,0.006402581,0.4684115,0.006118338,0.3228417,0.0004586607],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517758,0.0414272,0.001092471,0.0004961148,0.0003641341,0.0009689615,0.00009635062,0.0001760082,0.003602931],"genre_scores_gemma":[0.9901654,0.00216315,0.0005675724,0.001679969,0.0001575712,0.00004864256,0.0001035333,0.00004612492,0.005068072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3459401,"threshold_uncertainty_score":0.999963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009190733831052086,"score_gpt":0.2384143300954014,"score_spread":0.2292235962643493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}