{"id":"W4414293358","doi":"10.1021/acsmedchemlett.5c00398","title":"Design, Synthesis, and Biological Evaluation of Triazole-Linked Lignan–Monoterpenoid-Based Hybrid Molecules as Xanthine Oxidase Inhibitors with Potent In Vivo Efficacy","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Hyperuricemia; Xanthine oxidase; In vivo; Gout; Uric acid; In vitro; Cytotoxic T cell; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001465953,0.0003681573,0.0006967091,0.0001845326,0.00005555548,0.00001349732,0.0001879205,0.0001820911,0.00007619501],"category_scores_gemma":[0.001865152,0.0002727997,0.00007702316,0.0004150543,0.0004132079,0.00004930456,0.00005556875,0.0004388445,0.000002178009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703051,"about_ca_system_score_gemma":0.0004618819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008971549,"about_ca_topic_score_gemma":6.3757e-7,"domain_scores_codex":[0.997264,0.0002112054,0.0006449633,0.0006047772,0.0009018699,0.0003731939],"domain_scores_gemma":[0.99818,0.0007509624,0.0002518058,0.0004607912,0.0001702615,0.0001862139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001987684,0.0003243192,0.002629533,0.0002953996,0.0001525653,0.00035865,0.0001280605,0.0005305685,0.9898324,8.78439e-7,0.0004686391,0.003291305],"study_design_scores_gemma":[0.008134904,0.0002293725,0.003961796,0.001596664,0.0008846534,0.0001500459,0.0002242933,0.002088545,0.9824283,0.00001720039,0.00004104064,0.0002431707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875118,0.000784571,0.001893928,0.008585501,0.0000550654,0.0008944763,0.000006226627,0.00005405098,0.0002143449],"genre_scores_gemma":[0.9961302,0.00004578121,0.001251134,0.002287077,0.0001047348,0.0001094499,0.00003293465,0.00002479569,0.00001390304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008618353,"threshold_uncertainty_score":0.9999724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239043099029545,"score_gpt":0.2739808130101338,"score_spread":0.2515903820198383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}