{"id":"W4414293358","doi":"10.1021/acsmedchemlett.5c00398","title":"Design, Synthesis, and Biological Evaluation of Triazole-Linked Lignan–Monoterpenoid-Based Hybrid Molecules as Xanthine Oxidase Inhibitors with Potent In Vivo Efficacy","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Hyperuricemia; Xanthine oxidase; In vivo; Gout; Uric acid; In vitro; Cytotoxic T cell; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114062,0.0002680572,0.0001932861,0.0001710841,0.00008793588,0.000210377,0.000210458,0.0002737968,0.0010466],"category_scores_gemma":[0.00008658267,0.00008887288,0.0001810911,0.0001642312,0.00009276008,0.0001412407,0.0001088318,0.0002488443,0.0002731567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756203,"about_ca_system_score_gemma":0.00008668419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002534481,"about_ca_topic_score_gemma":0.0006217667,"domain_scores_codex":[0.9999604,0.000008553573,0.000002897686,0.000006704793,0.00001150599,0.00000990941],"domain_scores_gemma":[0.9999614,0.000004945964,0.00001304396,0.000002857279,0.00000765545,0.00001024809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132537,0.00007982578,0.00007319909,0.0001004103,0.00001456077,0.00009131782,0.00002222929,0.0005078123,0.9944783,0.0001506932,0.00006234911,0.004305955],"study_design_scores_gemma":[0.00008102013,0.003065709,0.001597657,0.00001575303,0.00006845253,0.0002901664,0.00002796293,0.001743159,0.988357,0.00004566279,0.004693238,0.00001418168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840351,0.005204763,0.007501734,0.0001158902,0.00003288932,0.0001990905,0.0003420019,0.00009227259,0.002476245],"genre_scores_gemma":[0.9892005,0.002473013,0.005480476,0.00006980939,0.0000114384,0.0001086853,0.0003723816,0.000008905366,0.002274844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010466,"threshold_uncertainty_score":0.003501236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239043099029545,"score_gpt":0.2739808130101338,"score_spread":0.2515903820198383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}