{"id":"W4414295899","doi":"10.1021/acsnano.4c15013","title":"AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; National Institute on Aging; European Research Council; Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology; Chan Zuckerberg Initiative; Teva Pharmaceutical Industries; Azrieli Foundation; Israel Science Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Transfection; Biodistribution; Internalization; Gene delivery; Tropism; Intracellular; Transgene; Genetic enhancement; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009976041,0.0001514077,0.0001335983,0.00005953226,0.0001228455,0.00004720503,0.0002413653,0.0001061371,0.00005907107],"category_scores_gemma":[0.0001093249,0.0001224469,0.00005342086,0.000252065,0.0001177664,0.000006274749,0.0001444858,0.0001112197,0.00003474748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001085883,"about_ca_system_score_gemma":0.0001899773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002767949,"about_ca_topic_score_gemma":0.00002373649,"domain_scores_codex":[0.998869,0.00009505267,0.0001563892,0.0003575124,0.000168324,0.0003537106],"domain_scores_gemma":[0.9993886,0.00002631208,0.00003272407,0.0003710004,0.00009647304,0.00008484694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002103987,0.00007527487,0.00219414,0.0000129916,0.00006850536,0.00001269487,0.00001007213,0.00001833385,0.9699211,0.0001844136,0.02533687,0.001955197],"study_design_scores_gemma":[0.000689102,0.0002908056,0.001821973,0.00001665688,0.00001295503,0.000002942277,0.00002043085,0.00003163229,0.8648508,0.00003456001,0.132097,0.0001311529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940971,0.0002950399,0.0004143499,0.004050355,0.00007892844,0.0001593912,0.00002372091,0.00002895404,0.0008521753],"genre_scores_gemma":[0.9916106,0.00004998906,0.0001887016,0.002910607,0.0001263836,0.00002661352,0.0001324701,0.00002067039,0.004934005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1067601,"threshold_uncertainty_score":0.4993241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00804256283905241,"score_gpt":0.2762042785872002,"score_spread":0.2681617157481478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}