{"id":"W4414295899","doi":"10.1021/acsnano.4c15013","title":"AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; National Institute on Aging; European Research Council; Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology; Chan Zuckerberg Initiative; Teva Pharmaceutical Industries; Azrieli Foundation; Israel Science Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Transfection; Biodistribution; Internalization; Gene delivery; Tropism; Intracellular; Transgene; Genetic enhancement; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000287949,0.0004525641,0.0001831981,0.0002290444,0.0001287694,0.0002316345,0.0002074572,0.0003961191,0.0009556659],"category_scores_gemma":[0.0003142662,0.0001503389,0.0002337832,0.0001255646,0.000208272,0.0001919905,0.0001831702,0.0003476282,0.0005888018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004083653,"about_ca_system_score_gemma":0.0002020522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047035,"about_ca_topic_score_gemma":0.001151021,"domain_scores_codex":[0.9998599,0.00001676606,0.000009910134,0.00004480298,0.0000481067,0.00002041009],"domain_scores_gemma":[0.9998902,0.00002538506,0.0000258926,0.000008361531,0.00004045461,0.000009784313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001462499,0.000005867115,0.00003878931,0.00001524571,0.000001614975,0.00001856135,0.000008841221,0.0002336648,0.9986896,0.00006871614,0.00002800796,0.000876432],"study_design_scores_gemma":[0.000002356475,0.00004856689,0.0002599322,0.000002469994,0.00000527724,0.00004005108,0.000006506784,0.003384316,0.9955657,0.00002391867,0.0006573352,0.000003538372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9058775,0.0008438574,0.08603632,0.0001566375,0.00005098559,0.000186736,0.0007402523,0.0006726445,0.00543507],"genre_scores_gemma":[0.9363707,0.0008669539,0.05541332,0.00009565047,0.00001141981,0.0003465085,0.001061576,0.0001498901,0.005683986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047035,"threshold_uncertainty_score":0.003197014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00804256283905241,"score_gpt":0.2762042785872002,"score_spread":0.2681617157481478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}