{"id":"W4414295928","doi":"10.1021/envhealth.5c00227","title":"Malignant Transformation of Human Uroepithelial Cells Induced by Long-Term Exposure to a Disinfection Byproduct─2,6-Dichlorobenzoquinone","year":2025,"lang":"en","type":"article","venue":"Environment & Health","topic":"Chemical Analysis and Environmental Impact","field":"Environmental Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Vinculin; Malignant transformation; Extracellular matrix; Cytoskeleton; Actin; Cell culture; Extracellular; Immunofluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004021574,0.0002730877,0.0003912375,0.00007629464,0.0002267086,0.00002128504,0.000225153,0.00009288055,0.002084985],"category_scores_gemma":[0.000005040473,0.0002485246,0.0001411591,0.0002689737,0.0001182251,0.0002162483,0.0001487291,0.0001746619,0.0002904871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008030312,"about_ca_system_score_gemma":0.0000106903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009934284,"about_ca_topic_score_gemma":0.00008472409,"domain_scores_codex":[0.9977015,0.00009887194,0.0006836421,0.0005472551,0.0004888953,0.0004798052],"domain_scores_gemma":[0.9990188,0.00001716945,0.0002050655,0.000459512,0.000001534714,0.0002978788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003453079,0.0007205532,0.03109446,0.00005629926,0.0000287135,6.044571e-7,0.0004976455,0.0008721674,0.9500917,0.000009917661,0.001454902,0.01513857],"study_design_scores_gemma":[0.0006919727,0.0008400473,0.534504,0.00007025996,0.00005025672,0.000001099301,0.00005687786,0.00003002471,0.4619252,0.00005501578,0.001475603,0.0002996238],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950316,0.0001097135,0.002019398,0.001520252,0.00008687097,0.0006316144,0.00003729975,0.00002820318,0.0005350731],"genre_scores_gemma":[0.9981703,0.0002344048,0.0001105785,0.0007376641,0.0000296843,0.00003430264,0.0001003732,0.00002000179,0.0005627277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5034095,"threshold_uncertainty_score":0.9999967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009464515839935453,"score_gpt":0.2544026104829064,"score_spread":0.2449380946429709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}