{"id":"W4414306677","doi":"10.1101/2025.09.15.676309","title":"Prion Seeding Activity in DNA Extractions: Implications for Laboratory Biosafety","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency","funders":"Legislative-Citizen Commission on Minnesota Resources; Minnesota Environment and Natural Resources Trust Fund; Canadian Food Inspection Agency; Creighton University","keywords":"Biosafety; DNA; DNA extraction; Nucleic acid; Infectivity; Recombinant DNA; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07446804,0.001438269,0.0008817826,0.002094008,0.001212624,0.003654965,0.002423563,0.001948929,0.001108413],"category_scores_gemma":[0.1575472,0.0008410929,0.0006011758,0.002333747,0.004578034,0.001569397,0.001508922,0.00156406,0.0006924932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002190699,"about_ca_system_score_gemma":0.002102351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006585073,"about_ca_topic_score_gemma":0.008410611,"domain_scores_codex":[0.9110239,0.03721909,0.008079256,0.009618392,0.03271233,0.001346957],"domain_scores_gemma":[0.7551553,0.1627854,0.02573901,0.01697831,0.03774834,0.001593515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002188221,0.0008423733,0.3992759,0.002404304,0.0005036703,0.0005272672,0.00647249,0.004094202,0.4406661,0.003093059,0.002585956,0.1373463],"study_design_scores_gemma":[0.00007061964,0.0041877,0.2238952,0.001202637,0.0004732291,0.002192023,0.002871031,0.01800935,0.7282628,0.003353251,0.01528207,0.0002002349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.728633,0.009691947,0.2413999,0.003333388,0.0009500241,0.001843531,0.001024111,0.001550646,0.01157344],"genre_scores_gemma":[0.8512192,0.00116552,0.1427454,0.001263278,0.0001110052,0.0005643177,0.0006000254,0.0001395647,0.002191642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07446804,"threshold_uncertainty_score":0.3938293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158205297263982,"score_gpt":0.2677720214665421,"score_spread":0.2519514917401439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}