{"id":"W4414307001","doi":"10.1101/2025.09.09.25335109","title":"Panorama of Chromosomal Instability in Lung Cancer","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Chromosome instability; Genome instability; Lung cancer; Carcinogenesis; Mutation; Somatic cell; Disease; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124004,0.0002346306,0.0003378246,0.001262429,0.0002285928,0.0006309568,0.0001354076,0.0002860378,0.002910389],"category_scores_gemma":[0.0006857893,0.0001245931,0.0002653469,0.001122951,0.0002702716,0.0002784655,0.0004653638,0.0003934987,0.000389056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002930463,"about_ca_system_score_gemma":0.0002204974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007258993,"about_ca_topic_score_gemma":0.001029097,"domain_scores_codex":[0.9996865,0.00004405591,0.0000176794,0.0001108835,0.0001020291,0.00003897241],"domain_scores_gemma":[0.9995796,0.00008780233,0.0001772425,0.00004624484,0.0000455228,0.00006366117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001401634,0.00007976576,0.5219606,0.0008120999,0.0008518122,0.001442032,0.0003039835,0.002419332,0.3078597,0.003625196,0.006083366,0.1531605],"study_design_scores_gemma":[0.00002150473,0.0002024565,0.9451881,0.00007304166,0.0002001455,0.004260347,0.0001701934,0.001779501,0.02585327,0.005092951,0.01713348,0.0000249702],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553465,0.0259655,0.00533925,0.0009342019,0.00008639217,0.00002339407,0.004895722,0.0003300169,0.007079036],"genre_scores_gemma":[0.9902219,0.00384665,0.001728048,0.0001843851,0.00009271512,0.000009962227,0.002443666,0.00003694398,0.001435867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002910389,"threshold_uncertainty_score":0.00973618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795192385681322,"score_gpt":0.3608732951840917,"score_spread":0.3429213713272785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}