{"id":"W4414307828","doi":"10.1080/14786419.2025.2559778","title":"Integrated biological and chemical investigation of papuan marine organisms for the discovery of potential cytotoxic marine natural products","year":2025,"lang":"en","type":"article","venue":"Natural Product Research","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Badan Riset dan Inovasi Nasional","keywords":"Cheminformatics; Cytotoxicity; Cytotoxic T cell; Biological activity; Sponge; Chemical structure; Chemical toxicity; Chemical biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193309,0.0004290812,0.0003194204,0.0009841012,0.0001630012,0.000305771,0.000174361,0.0001704143,0.0006924681],"category_scores_gemma":[0.0001479276,0.0001326013,0.0003736672,0.000623569,0.0001465531,0.0002895324,0.0003736321,0.0002240264,0.0001473691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001117837,"about_ca_system_score_gemma":0.0002959811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003831199,"about_ca_topic_score_gemma":0.0009709187,"domain_scores_codex":[0.9999163,0.00001045337,0.000007383287,0.00001986572,0.00003414033,0.00001185207],"domain_scores_gemma":[0.9999325,0.00001275546,0.00002118698,0.000006862895,0.00001566837,0.00001103291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006557925,0.00003745142,0.002659445,0.0002054368,0.00003619921,0.0001855967,0.00002547955,0.0004180536,0.9803261,0.0000525059,0.00001610046,0.01597204],"study_design_scores_gemma":[0.00002150921,0.001625261,0.06973533,0.00003342345,0.0002830565,0.001436344,0.000180562,0.003908574,0.9184666,0.0003078292,0.003971036,0.00003047818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848903,0.002875235,0.008878999,0.00007535185,0.000009636467,0.0001078754,0.000693776,0.00008587554,0.002382994],"genre_scores_gemma":[0.9759929,0.003167796,0.01845879,0.00006785656,0.00001102803,0.00007354971,0.0009385077,0.00000841223,0.001281098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009841012,"threshold_uncertainty_score":0.002316475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02383444556161648,"score_gpt":0.3105023956413793,"score_spread":0.2866679500797629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}