{"id":"W4414309369","doi":"10.1016/j.neo.2025.101229","title":"Proteomic analysis uncovers biological diversity in molecularly defined endometrial carcinomas","year":2025,"lang":"en","type":"article","venue":"Neoplasia","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Terry Fox Research Institute; Vancouver General Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Spinal Cord Injury BC","funders":"Canadian Cancer Society Research Institute; BC Cancer Foundation; Canada Excellence Research Chairs, Government of Canada; Canada Research Chairs","keywords":"Endometrial cancer; Replicate; Gene expression profiling; Proteome; Biopsy; Molecular biomarkers; Proteomics; Profiling (computer programming)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002647071,0.0001481783,0.0003327575,0.001080452,0.0002315201,0.000507202,0.0001323613,0.000264229,0.000247178],"category_scores_gemma":[0.0008730157,0.0001559575,0.0002056622,0.0006507709,0.0002285899,0.0002647435,0.0004704584,0.0001936141,0.0001128334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001525114,"about_ca_system_score_gemma":0.0001106768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003613776,"about_ca_topic_score_gemma":0.0003995091,"domain_scores_codex":[0.9998068,0.00003080571,0.00002553472,0.00005754585,0.00004713069,0.00003222358],"domain_scores_gemma":[0.9997544,0.00005589067,0.00008225776,0.00003374127,0.00004080498,0.00003299305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004775871,0.00003692355,0.1701071,0.0001130643,0.0001537952,0.0003818185,0.0004778561,0.0003140132,0.8178681,0.0001883318,0.0001389524,0.009742489],"study_design_scores_gemma":[0.000008246344,0.0001337205,0.9729306,0.000009365448,0.00006073874,0.001843529,0.0004141981,0.001215728,0.02193953,0.0003141071,0.001118761,0.00001158702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990096,0.0003109462,0.0003966727,0.00001610385,0.000001526514,0.000004181521,0.0001150989,0.000005297192,0.0001405442],"genre_scores_gemma":[0.9983733,0.0002098248,0.0008811918,0.0000300232,0.000006159729,0.00001152075,0.0003781332,0.000004132316,0.0001057425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080452,"threshold_uncertainty_score":0.001399934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025160748474135,"score_gpt":0.2842436826549769,"score_spread":0.2539920751702355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}