{"id":"W4414309670","doi":"10.1200/jco-25-01235","title":"Beyond the Guided Missile Paradigm: Embracing the Complexity of Antibody-Drug Conjugates","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Missile; Conjugate; Pandemic; Key (lock); Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002631633,0.0006194952,0.001277049,0.0005760787,0.001093361,0.004103587,0.001663218,0.002883154,0.004695037],"category_scores_gemma":[0.004244504,0.0005125375,0.000641738,0.0003377828,0.004253197,0.008094404,0.003088441,0.004456657,0.001344481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001387106,"about_ca_system_score_gemma":0.001132139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000560939,"about_ca_topic_score_gemma":0.001035786,"domain_scores_codex":[0.9986204,0.000649054,0.00003733614,0.0001664234,0.000370951,0.0001558447],"domain_scores_gemma":[0.998211,0.001097088,0.0001622455,0.0002384445,0.000175907,0.0001153394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003390702,0.000166814,0.001331417,0.00117869,0.000118442,0.001212803,0.0007129125,0.02778391,0.04349197,0.77804,0.01096962,0.1346543],"study_design_scores_gemma":[0.0001007218,0.001211272,0.0008189995,0.0004470421,0.0001015581,0.003246216,0.0008739306,0.07329371,0.03110486,0.6799313,0.2087201,0.0001503097],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.1228392,0.1261904,0.5523219,0.06932757,0.003905221,0.0002819132,0.0003107985,0.0008937669,0.1239293],"genre_scores_gemma":[0.8239326,0.05542564,0.08915728,0.009421938,0.001522718,0.0003114733,0.0001263441,0.0001851106,0.01991688],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.004695037,"threshold_uncertainty_score":0.01570642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3070645395625706,"score_gpt":0.579066841590274,"score_spread":0.2720023020277034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}