{"id":"W4414312813","doi":"10.1016/j.humimm.2025.111424","title":"HLA molecular mismatch categories revised and validated using updated HLAMatchmaker™ software","year":2025,"lang":"en","type":"article","venue":"Human Immunology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Manitoba Health; George & Fay Yee Centre for Healthcare Innovation; University of Manitoba","funders":"","keywords":"Human leukocyte antigen; Software; Software tool; Pattern recognition (psychology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003537271,0.001636535,0.001058432,0.006035579,0.0009504144,0.003696439,0.002242241,0.0009851228,0.05214533],"category_scores_gemma":[0.01476202,0.001298482,0.002080175,0.003231016,0.0004206604,0.003050264,0.002188237,0.001934729,0.027115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009649759,"about_ca_system_score_gemma":0.002403617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008298471,"about_ca_topic_score_gemma":0.007802555,"domain_scores_codex":[0.998145,0.0002057035,0.0003734274,0.0004610012,0.0005954232,0.0002195419],"domain_scores_gemma":[0.9936813,0.001853344,0.000495136,0.001488809,0.002275699,0.000205721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001723776,0.0002572194,0.03209563,0.001542196,0.000534619,0.0008384277,0.000756349,0.009359481,0.01058353,0.01250842,0.4380941,0.4917063],"study_design_scores_gemma":[0.0004001113,0.000142025,0.01810095,0.0006694008,0.000555338,0.001677763,0.0003322402,0.06460761,0.03782935,0.02808977,0.8473024,0.0002930506],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04627842,0.001126701,0.3973903,0.001018413,0.001286469,0.0008727691,0.129767,0.3810459,0.04121405],"genre_scores_gemma":[0.1437405,0.001228171,0.497705,0.001223683,0.0003212984,0.001260591,0.2697004,0.04609311,0.03872725],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.05214533,"threshold_uncertainty_score":0.1744435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255366955852778,"score_gpt":0.2607496312710244,"score_spread":0.2481959617124966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}