{"id":"W4414320784","doi":"10.29173/hsi502","title":"A Multi-Omics Therapeutic Approach using SAHA, SP600125, and Exercise to Modulate BDNF levels in Major Depressive Disorder","year":2025,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McMaster University","funders":"","keywords":"Context (archaeology); Major depressive disorder; Epigenetics; Mood; Brain-derived neurotrophic factor; Histone deacetylase; Vorinostat; Neurotrophic factors; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009427229,0.0001736523,0.0004440585,0.0005439959,0.0003038744,0.00004104548,0.000189636,0.00007841683,0.000005435485],"category_scores_gemma":[0.00008311318,0.0001480527,0.00002890851,0.001319896,0.0004653535,0.0002269653,0.0001625731,0.0002261613,0.000005889436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404232,"about_ca_system_score_gemma":0.0009362812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006402371,"about_ca_topic_score_gemma":0.00003327597,"domain_scores_codex":[0.9980507,0.000037437,0.0003748039,0.0006029283,0.0002838025,0.0006502673],"domain_scores_gemma":[0.9990565,0.00002803124,0.00008359196,0.0003935682,0.00008650926,0.0003518442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004382211,0.001245102,0.1781394,0.001608882,0.00004580411,0.0000531409,0.04835876,0.002316815,0.05373972,0.001710667,0.0001603142,0.7121832],"study_design_scores_gemma":[0.003440306,0.00009353743,0.918606,0.00073799,0.00006863381,0.00005177494,0.002563872,0.07103557,0.001664051,0.0003664352,0.001075401,0.0002964371],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585361,0.009379718,0.02885572,0.001349379,0.0004191843,0.001355111,0.000004097004,0.00003392465,0.0000667987],"genre_scores_gemma":[0.9667752,0.00029937,0.0287073,0.003766497,0.00006283353,0.00004341613,0.000001921529,0.00001534177,0.0003280939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7404667,"threshold_uncertainty_score":0.6037415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1201500534356233,"score_gpt":0.4124288068025504,"score_spread":0.2922787533669271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}