{"id":"W4414320804","doi":"10.29173/hsi500","title":"Exercise as an Adjunctive Treatment Modality for Major Depressive Disorder: A Multi-Omics Perspective","year":2025,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"Physical Activity and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Major depressive disorder; Aerobic exercise; Adjunctive treatment; Clinical trial; Randomized controlled trial; Antidepressant; Psychological intervention; Depression (economics); Kynurenine pathway; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004885091,0.0002186364,0.0006132554,0.0002341085,0.001040981,0.0000402005,0.0002035413,0.00008304136,0.000007253854],"category_scores_gemma":[0.0002129267,0.0001749543,0.0001186986,0.0007344976,0.0009605454,0.000468488,0.00007151244,0.0002065613,0.00001125384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002009703,"about_ca_system_score_gemma":0.005435527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006142131,"about_ca_topic_score_gemma":0.000486102,"domain_scores_codex":[0.9977108,0.00004604208,0.0003051419,0.0008643689,0.0003263463,0.0007472792],"domain_scores_gemma":[0.9981737,0.0001226052,0.0001549788,0.000510409,0.000416247,0.0006220496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01338673,0.04826379,0.03162664,0.002822233,0.0002514696,0.000038942,0.1253528,0.000253507,0.00426749,0.236713,0.001044444,0.535979],"study_design_scores_gemma":[0.0353053,0.02532183,0.663613,0.001902745,0.0004800815,0.00004304798,0.064315,0.05752289,0.02007519,0.1272553,0.002895721,0.001269938],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701003,0.0007593358,0.007493361,0.01676275,0.0005437843,0.00368741,0.00006986612,0.0001243,0.00045887],"genre_scores_gemma":[0.9929192,0.0003443929,0.003182474,0.002594496,0.0001652112,0.0004792115,0.00002015697,0.00001341223,0.0002814563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6319863,"threshold_uncertainty_score":0.9642392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1070302163037468,"score_gpt":0.4620610349337091,"score_spread":0.3550308186299623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}