{"id":"W4414320804","doi":"10.29173/hsi500","title":"Exercise as an Adjunctive Treatment Modality for Major Depressive Disorder: A Multi-Omics Perspective","year":2025,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"Physical Activity and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Major depressive disorder; Aerobic exercise; Adjunctive treatment; Clinical trial; Randomized controlled trial; Antidepressant; Psychological intervention; Depression (economics); Kynurenine pathway; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004486165,0.0005646895,0.003488962,0.003983475,0.0003592758,0.002102225,0.0008013949,0.001117225,0.002319876],"category_scores_gemma":[0.007008696,0.0002820733,0.002452321,0.003531722,0.0004025478,0.001215236,0.000790677,0.00107457,0.0002916279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001280191,"about_ca_system_score_gemma":0.002880739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003410015,"about_ca_topic_score_gemma":0.01036475,"domain_scores_codex":[0.9974276,0.001180426,0.0006949384,0.0002565406,0.0003734511,0.00006693148],"domain_scores_gemma":[0.9931802,0.005326937,0.0007363992,0.0001079881,0.000560496,0.00008797425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0008745758,0.0001618946,0.005361797,0.2933133,0.007592499,0.0001849057,0.0005191556,0.0004551163,0.001414656,0.003082399,0.008052645,0.678987],"study_design_scores_gemma":[0.0009157414,0.002271358,0.06817617,0.6147183,0.03432373,0.001198354,0.001742698,0.001356956,0.0008687351,0.01091294,0.2633492,0.0001658625],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.001866153,0.9931771,0.0003713477,0.003032031,0.0002883747,0.0001221405,0.0003457188,0.00000673644,0.0007903762],"genre_scores_gemma":[0.02201224,0.9700148,0.003413172,0.002719353,0.0008208789,0.0003695428,0.0003699028,0.000007012516,0.000273172],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004486165,"threshold_uncertainty_score":0.02372533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1070302163037468,"score_gpt":0.4620610349337091,"score_spread":0.3550308186299623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}