{"id":"W4414327069","doi":"10.58931/cdt.2025.63144","title":"Off-Label Isotretinoin in Dermatologic Conditions: Doses, Duration, and Data","year":2025,"lang":"en","type":"article","venue":"Canadian dermatology today.","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Western University","funders":"","keywords":"Isotretinoin; Acne; Adverse effect; Acne treatment; Clinical Practice; Clinical trial; Pharmacodynamics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000710708,0.0001411113,0.0003184744,0.0003720163,0.0001691425,0.00001893261,0.000119931,0.0002032844,0.0001098993],"category_scores_gemma":[0.0001553885,0.000120956,0.0000159565,0.0002568482,0.0001479097,0.0001119235,0.0000544485,0.0001555968,0.00004611247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008246238,"about_ca_system_score_gemma":0.0006217991,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.006988607,"about_ca_topic_score_gemma":0.08963268,"domain_scores_codex":[0.9989493,0.00006533172,0.0002844938,0.0003233682,0.00004491608,0.0003325737],"domain_scores_gemma":[0.9991683,0.00009046542,0.00004081747,0.0004409183,0.0000341872,0.0002253012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002536925,0.00008418653,0.6656133,0.0001212303,0.00009791936,0.002762695,0.0001095768,3.838153e-7,0.00004151751,0.005482428,0.3221367,0.003524671],"study_design_scores_gemma":[0.007450142,0.00008052798,0.5227048,0.0004062532,0.0003203901,0.006566009,0.000532388,0.003449987,0.0004837159,0.002620285,0.4549792,0.0004063235],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8820971,0.009849755,0.00002903909,0.09416781,0.0002300868,0.0006337988,0.0001478242,0.00005257582,0.01279198],"genre_scores_gemma":[0.983867,0.0005416119,0.0002047849,0.01367074,0.00001398899,0.00003211297,0.0007778467,0.000008009801,0.0008839181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1429085,"threshold_uncertainty_score":0.999624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026124767718329,"score_gpt":0.3131785972056946,"score_spread":0.2929173495285113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}