{"id":"W4414327069","doi":"10.58931/cdt.2025.63144","title":"Off-Label Isotretinoin in Dermatologic Conditions: Doses, Duration, and Data","year":2025,"lang":"en","type":"article","venue":"Canadian dermatology today.","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Western University","funders":"","keywords":"Isotretinoin; Acne; Adverse effect; Acne treatment; Clinical Practice; Clinical trial; Pharmacodynamics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003786783,0.0005049232,0.001574124,0.001761522,0.0002784506,0.001369001,0.0006825539,0.0008558317,0.004910622],"category_scores_gemma":[0.005987469,0.0002072984,0.001946694,0.003833496,0.0004483528,0.0007531625,0.0002846916,0.001505459,0.001133551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001660428,"about_ca_system_score_gemma":0.001415528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004541645,"about_ca_topic_score_gemma":0.01028389,"domain_scores_codex":[0.9975728,0.0006078869,0.0005564072,0.0002091462,0.0009293928,0.0001242805],"domain_scores_gemma":[0.9901695,0.003949269,0.003103775,0.0005274068,0.001662363,0.0005877063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0215726,0.001564451,0.01318051,0.01587928,0.002585827,0.00021555,0.0001435896,0.0009630776,0.005780922,0.0006706693,0.01519436,0.9222492],"study_design_scores_gemma":[0.013608,0.03631278,0.2672876,0.02447238,0.01343665,0.004024473,0.0003882493,0.00157194,0.013685,0.001810973,0.6231589,0.000243176],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.05547242,0.9058782,0.001613159,0.001682601,0.0003998547,0.0007821455,0.009696605,0.00009246244,0.02438259],"genre_scores_gemma":[0.3317962,0.6375569,0.003476261,0.004056708,0.001118536,0.000871362,0.01523433,0.00009043258,0.005799299],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004910622,"threshold_uncertainty_score":0.02002668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026124767718329,"score_gpt":0.3131785972056946,"score_spread":0.2929173495285113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}