{"id":"W4414328405","doi":"10.1101/2025.09.15.676396","title":"The DREAM complex links somatic mutation, lifespan, and disease","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"National Institutes of Health","keywords":"Dream; Somatic cell; Regulator; Disease; Mutation; Psychological repression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002912992,0.0002305742,0.0002463301,0.0005056505,0.0001737904,0.0005207689,0.0001726639,0.0002426413,0.001800669],"category_scores_gemma":[0.0002520098,0.0001681733,0.0001780296,0.0002043691,0.000280866,0.0001997051,0.0005152841,0.0002700967,0.0004045193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541702,"about_ca_system_score_gemma":0.000174799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005896551,"about_ca_topic_score_gemma":0.0005449293,"domain_scores_codex":[0.9998883,0.00001693198,0.00001082499,0.00003506076,0.00003265767,0.00001623083],"domain_scores_gemma":[0.9997998,0.00002746645,0.00008724524,0.00002502483,0.00001744745,0.00004306774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001007951,0.00004474742,0.04874149,0.0002471822,0.0001686077,0.0004867766,0.0001453026,0.001007675,0.9324127,0.0024363,0.001133838,0.01216736],"study_design_scores_gemma":[0.00005393803,0.0004003679,0.3584154,0.0001084232,0.0002917131,0.004324269,0.0003608554,0.005523756,0.6052417,0.00714411,0.01807651,0.0000588764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813817,0.006501653,0.006546856,0.0004013052,0.00004972607,0.0000100552,0.002893728,0.000246938,0.001968154],"genre_scores_gemma":[0.9918566,0.001292185,0.002428062,0.00007211856,0.00001420099,0.000008558507,0.001476105,0.00003770447,0.002814504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001800669,"threshold_uncertainty_score":0.006023824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099079124179093,"score_gpt":0.2254033703846496,"score_spread":0.2144125791428586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}