{"id":"W4414335677","doi":"10.1038/s41588-025-02301-3","title":"Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks","year":2025,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Michael Smith Health Research BC; National Human Genome Research Institute; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute on Aging; Crohn's and Colitis Foundation","keywords":"Gene; T cell; Epigenetics; Autoimmune disease; Gene expression; Regulation of gene expression; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002336646,0.0003814355,0.0003190883,0.0003942575,0.0002020319,0.0003482467,0.0002143845,0.0002763349,0.00220319],"category_scores_gemma":[0.0003437306,0.000151399,0.0004593252,0.0003764492,0.0002704469,0.0001022946,0.0003277777,0.0005437818,0.0002926002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000231926,"about_ca_system_score_gemma":0.0001659361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005822887,"about_ca_topic_score_gemma":0.001768356,"domain_scores_codex":[0.999685,0.00004259618,0.00002262965,0.0001178728,0.0000866401,0.00004517757],"domain_scores_gemma":[0.9997765,0.00009397745,0.00005698847,0.00002956027,0.00001472877,0.00002818942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001127824,0.00001764033,0.002370471,0.00004703504,0.00004529782,0.000133455,0.00001931931,0.0003796058,0.9934613,0.0001484579,0.00005617714,0.00320866],"study_design_scores_gemma":[0.00004537117,0.0005263864,0.05406169,0.00001572016,0.000280505,0.001329587,0.00006822559,0.004271473,0.9353185,0.0005034328,0.003560372,0.0000186382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805706,0.0007378769,0.01509846,0.00009489215,0.0000247193,0.00003999403,0.001647367,0.0003101845,0.001475854],"genre_scores_gemma":[0.9901287,0.0003736314,0.00744972,0.00009146509,0.000008744234,0.00003353104,0.001083977,0.00004897328,0.0007812355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00220319,"threshold_uncertainty_score":0.007370412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002361817945874929,"score_gpt":0.2183069433880789,"score_spread":0.215945125442204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}