{"id":"W4414342415","doi":"10.1101/2025.09.18.25335917","title":"Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Foreign, Commonwealth and Development Office; European Commission; National Institute for Health and Care Research; Government of the United Kingdom; Wellcome Trust","keywords":"Harm; Tuberculosis; Do no harm; Risk assessment; Test (biology); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08459159,0.001607304,0.002094904,0.001750971,0.000605716,0.00245254,0.001687034,0.003109718,0.003183568],"category_scores_gemma":[0.2568299,0.0006815903,0.00474237,0.001441524,0.003573768,0.004377153,0.003077313,0.003120407,0.0003851088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004142154,"about_ca_system_score_gemma":0.004987849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007509518,"about_ca_topic_score_gemma":0.006376805,"domain_scores_codex":[0.916539,0.07121125,0.002131314,0.003208655,0.005438512,0.001471197],"domain_scores_gemma":[0.7939582,0.1598363,0.0227688,0.01368827,0.00748511,0.002263419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009004628,0.001104844,0.446705,0.006136178,0.02050812,0.0008344875,0.001584779,0.08651251,0.0006647413,0.05222705,0.01080259,0.363915],"study_design_scores_gemma":[0.002251303,0.01583368,0.3724423,0.009571629,0.02042753,0.002973324,0.002065788,0.172843,0.005508,0.3480867,0.04744291,0.0005537898],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6473013,0.06235183,0.1350276,0.09448351,0.002356229,0.003639016,0.006875178,0.0005724672,0.04739293],"genre_scores_gemma":[0.9810986,0.001761863,0.01119488,0.0042645,0.0001966675,0.0005105924,0.0002930824,0.00003237757,0.0006473607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08459159,"threshold_uncertainty_score":0.4473684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2307748991497812,"score_gpt":0.4713144617145875,"score_spread":0.2405395625648064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}