{"id":"W4414343908","doi":"10.3390/proteomes13030045","title":"Comparative Analysis of Plasma Extracellular Vesicle Isolation Methods for Purity Assessment and Biomarker Discovery","year":2025,"lang":"en","type":"article","venue":"Proteomes","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Carleton University; Institut Universitaire de Gériatrie de Montréal; National Research Council Canada","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biomarker discovery; Biomarker; Extracellular vesicles; Proteomics; Extracellular vesicle; Isolation (microbiology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004569034,0.0001202578,0.0002650668,0.000128454,0.00006706019,0.00003440994,0.0001080091,0.00008470228,0.000009482753],"category_scores_gemma":[0.00007502458,0.0001149196,0.000147043,0.000256761,0.0001111,0.00001143299,0.00009675963,0.00004100487,1.853503e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001898766,"about_ca_system_score_gemma":0.00007452233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006894639,"about_ca_topic_score_gemma":0.000005827957,"domain_scores_codex":[0.9990741,0.0001631219,0.0002508002,0.000315901,0.00006541543,0.0001306787],"domain_scores_gemma":[0.9993915,0.00007813856,0.0001279281,0.0002785723,0.00008517714,0.00003866427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132691,0.0001183152,0.01275216,0.0000805798,0.001058205,2.460627e-7,0.00004121328,0.00009268186,0.9783315,0.001696321,0.00007170094,0.005624364],"study_design_scores_gemma":[0.0005862969,0.000100707,0.05848725,0.00001453538,0.0007762429,2.614884e-7,0.0001238287,0.04185956,0.894681,0.001146727,0.002070932,0.0001527101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5944293,0.002040081,0.402689,0.000065981,0.00002755731,0.0004594447,0.00003614558,0.000004839943,0.0002476185],"genre_scores_gemma":[0.901395,0.00003851593,0.09783133,0.00001920406,0.0000121113,0.0001451495,0.000124763,0.000005651894,0.0004283306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3069656,"threshold_uncertainty_score":0.4686284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02510328980114249,"score_gpt":0.397854250892881,"score_spread":0.3727509610917385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}