{"id":"W4414352735","doi":"10.1101/2025.09.17.676245","title":"Dynamic Regulation of the Immune Repertoire of Bacteria","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Immune system; Coevolution; Population; Repertoire; Immunological memory; Acquired immune system; Archaea","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754577,0.0001510895,0.0002164718,0.0002629785,0.0001788379,0.0007141777,0.00031202,0.0004022394,0.001017319],"category_scores_gemma":[0.0007982422,0.0001580117,0.000170694,0.0001409739,0.0004527408,0.0005841737,0.0004010232,0.0003296614,0.0002531998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004636711,"about_ca_system_score_gemma":0.0001849166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003130187,"about_ca_topic_score_gemma":0.0002269018,"domain_scores_codex":[0.9998705,0.00002828099,0.000004788843,0.00003547697,0.00003030992,0.00003058799],"domain_scores_gemma":[0.9998196,0.00007041884,0.00003722001,0.00002064555,0.00002552362,0.00002672752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000127338,0.00008017569,0.007792293,0.0001057242,0.00004073939,0.0001497198,0.0002263923,0.05604491,0.8816292,0.03091837,0.0005539603,0.02233107],"study_design_scores_gemma":[0.00005727954,0.0003046799,0.03018142,0.00004419674,0.0000409353,0.0005212359,0.0004965485,0.7417122,0.1718327,0.04925091,0.005480845,0.0000770621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777505,0.0004642106,0.01732314,0.0002487243,0.00001543904,0.000005609329,0.00004285237,0.0001116409,0.004037714],"genre_scores_gemma":[0.997134,0.0001435874,0.002216203,0.00003674349,0.000003946483,0.000007381507,0.00001912146,0.00001314673,0.0004259374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001017319,"threshold_uncertainty_score":0.003403306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007372038307823418,"score_gpt":0.2327325159832059,"score_spread":0.2253604776753824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}