{"id":"W4414362267","doi":"10.1111/cts.70366","title":"A Multi‐Scale Mechanistic Model of Ulcerative Colitis to Investigate the Effects of Selective Suppression of <scp>IL</scp> ‐6 Trans‐Signaling","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"PricewaterhouseCoopers (Canada)","funders":"","keywords":"Ulcerative colitis; Signal transduction; Colitis; Inflammation; Cytokine; Stimulation; Glycoprotein 130; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382058,0.0004305395,0.0005187026,0.0001778109,0.0001871693,0.0004304666,0.0007132238,0.0008440788,0.00211777],"category_scores_gemma":[0.0002756292,0.0001917654,0.000621339,0.0001371816,0.0003851885,0.0003282073,0.0004568317,0.000697925,0.0001497456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004129042,"about_ca_system_score_gemma":0.0004446461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003029661,"about_ca_topic_score_gemma":0.001728763,"domain_scores_codex":[0.9999194,0.00001544844,0.000003405441,0.00002608664,0.00001917687,0.00001635162],"domain_scores_gemma":[0.9998164,0.00007409073,0.00004537021,0.00001520581,0.00001969483,0.00002929779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00014459,0.0001655174,0.0006821422,0.0001236008,0.00003142082,0.0001824404,0.00002270213,0.9334283,0.0607001,0.002947816,0.0002135202,0.001357769],"study_design_scores_gemma":[0.00005260668,0.0003012209,0.0007685416,0.000005424713,0.00002735567,0.00004210509,0.00002358094,0.9909976,0.006102066,0.000828857,0.0008371982,0.00001349702],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9028829,0.000609517,0.08190931,0.0006112902,0.000121039,0.0001472486,0.00118179,0.0002570855,0.0122798],"genre_scores_gemma":[0.98772,0.0003324402,0.008535412,0.00006425095,0.000008214807,0.0001673287,0.0002639426,0.00001643066,0.002891955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003029661,"threshold_uncertainty_score":0.007084668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04253440801044542,"score_gpt":0.354046848845398,"score_spread":0.3115124408349526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}