{"id":"W4414371835","doi":"10.1016/j.ijrobp.2025.08.039","title":"Cross-Cancer Analysis Reveals a Distinct Pattern of Immune Modulation During Curative Radiation Therapy","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Terry Fox Research Institute; Canada Foundation for Innovation; Princess Margaret Cancer Foundation; Pfizer; Bristol-Myers Squibb","keywords":"Immune system; Myeloid cells; Immune modulation; Myeloid; Effector; Radiation therapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447323,0.0001739326,0.0003000305,0.0004635188,0.0001696817,0.0004797049,0.0001683419,0.0002793342,0.002080405],"category_scores_gemma":[0.0003295461,0.000136164,0.0002642522,0.0002441292,0.0001797356,0.0002137016,0.0002528589,0.0004598669,0.0004490502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082882,"about_ca_system_score_gemma":0.0001125034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000311363,"about_ca_topic_score_gemma":0.0002966266,"domain_scores_codex":[0.9997872,0.00003688014,0.000009658893,0.0000431027,0.00004239206,0.0000808003],"domain_scores_gemma":[0.9998128,0.00003937944,0.00004939015,0.00003108519,0.0000307055,0.00003672924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005824702,0.00004669704,0.004212181,0.00003140854,0.00002174905,0.00006055668,0.00004863324,0.00007985406,0.9915923,0.0001239525,0.00006343659,0.00313674],"study_design_scores_gemma":[0.00003630976,0.002123279,0.4966423,0.00002615424,0.000167647,0.001597857,0.0003223648,0.002348946,0.4913594,0.0003594927,0.004995405,0.00002073112],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967435,0.001238575,0.0007366443,0.00002085527,0.00001007089,0.00001364628,0.00009201347,0.0000263713,0.001118401],"genre_scores_gemma":[0.9986925,0.0002412818,0.0001952762,0.00004074967,0.000007611352,0.00001250136,0.0001639322,0.00001245401,0.0006337767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002080405,"threshold_uncertainty_score":0.006959677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912560161991737,"score_gpt":0.3728628446261436,"score_spread":0.3537372430062262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}