{"id":"W4414373149","doi":"10.1101/2025.09.17.676911","title":"Acute Pericentral Liver Injury Induces a Novel Transient Hepatocyte Population","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Hepatocyte; Liver injury; Population; Immune system; Crosstalk; Regulator; Intracellular; Hepatic stellate cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452047,0.0001624104,0.0002179077,0.0002241694,0.0001178683,0.0003089492,0.0001069564,0.0001510411,0.001117482],"category_scores_gemma":[0.00009414436,0.00009547689,0.0001250805,0.0001095899,0.0002056371,0.00009995824,0.0002863292,0.0003120944,0.0003237623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001540931,"about_ca_system_score_gemma":0.0001171086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002971208,"about_ca_topic_score_gemma":0.000559767,"domain_scores_codex":[0.9998293,0.00002490576,0.00001327947,0.00004891392,0.00004451973,0.00003907121],"domain_scores_gemma":[0.9998677,0.00001930832,0.00003116158,0.00002518402,0.00001965869,0.00003707085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001087381,0.00001390775,0.0005214043,0.00001368039,0.000001822464,0.00006830924,0.0000195899,0.0000160028,0.998193,0.00006367741,0.00002741925,0.0009524481],"study_design_scores_gemma":[0.00001484433,0.0003811575,0.02164366,0.00000576071,0.000009499101,0.0005296395,0.0000930418,0.0006243003,0.9742101,0.00008493775,0.002398523,0.000004430317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901011,0.0007776733,0.007269245,0.00006190572,0.00002118987,0.00004223886,0.0003003177,0.0001449259,0.00128128],"genre_scores_gemma":[0.9946752,0.0002513085,0.002138927,0.00005340547,0.00001083144,0.00004456793,0.0003302748,0.00002497827,0.002470622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117482,"threshold_uncertainty_score":0.003738284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683798982473315,"score_gpt":0.249106913562672,"score_spread":0.2322689237379388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}