{"id":"W4414379657","doi":"10.1093/molehr/gaaf047","title":"Permutation tests to assess sex differences in omics data","year":2025,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"B.C. Women's Hospital & Health Centre; BC Children's Hospital; Women's Health Research Institute; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Spurious relationship; Permutation (music); Omics; False discovery rate; Statistical hypothesis testing; Resampling; Multiple comparisons problem","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000380471,0.0001175619,0.0001220554,0.0001035564,0.00007635638,0.00005470454,0.000312497,0.0001033675,0.000003092559],"category_scores_gemma":[0.00009549517,0.0001251109,0.00002614424,0.0001778704,0.00002986584,0.000006529043,0.0002813105,0.000095712,0.000004784115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002416157,"about_ca_system_score_gemma":0.00004661984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002963584,"about_ca_topic_score_gemma":0.00009689986,"domain_scores_codex":[0.9988832,0.00004595244,0.0002514462,0.0005643773,0.00008928921,0.0001657316],"domain_scores_gemma":[0.998758,0.000003501135,0.00005804236,0.001096581,0.00005046076,0.0000334342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003359052,0.00009582317,0.009198342,0.00004878494,0.00005236843,0.000003912614,0.0001424667,0.001271123,0.9572823,0.001297099,0.002442599,0.02813156],"study_design_scores_gemma":[0.002094744,0.0006135569,0.1879424,0.0001917016,0.0001276886,0.00004470266,0.0008895087,0.007638702,0.7339094,0.01186007,0.05319193,0.001495643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709769,0.0002871154,0.0264306,0.0004260465,0.0002492677,0.0002949987,0.000008614395,0.00001466081,0.001311773],"genre_scores_gemma":[0.996789,0.00002262584,0.001161955,0.0002954292,0.000138673,0.00002067026,0.0005785559,0.00001095705,0.0009821026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.223373,"threshold_uncertainty_score":0.5101875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808049547343004,"score_gpt":0.3123176409294104,"score_spread":0.2742371454559803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}