{"id":"W4414381536","doi":"10.1016/j.chom.2025.08.011","title":"Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication","year":2025,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Immune system; Flagellin; Commensalism; Bacteria; Host (biology); Function (biology); Gut flora; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003716897,0.0004188013,0.0004008081,0.0001836031,0.0005227525,0.00009419535,0.000643941,0.0004751955,0.00005951314],"category_scores_gemma":[0.00005301886,0.0004446569,0.0002268071,0.0003702702,0.0002151812,0.0000125554,0.0002858385,0.0004582771,0.00004278391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001084778,"about_ca_system_score_gemma":0.0003257874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002375869,"about_ca_topic_score_gemma":0.0001417537,"domain_scores_codex":[0.9976115,0.0003615456,0.0006236704,0.0006730969,0.00008883836,0.000641412],"domain_scores_gemma":[0.9981465,0.00005269009,0.0002100425,0.001252591,0.0002144671,0.0001237082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009850352,0.0001835032,0.002714495,0.0002399284,0.00007358622,0.00001271659,0.0002003058,0.00002999206,0.9945593,0.00001324724,0.0008480159,0.0001397977],"study_design_scores_gemma":[0.002417689,0.0001232738,0.07706258,0.0002073674,0.00006476945,0.00002233917,0.00009155914,0.00001819494,0.8973978,0.000005471572,0.02217546,0.0004134663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873955,0.009156061,0.001086794,0.0008564749,0.0002270003,0.0006382227,0.0001165675,0.00007974789,0.0004436243],"genre_scores_gemma":[0.9886864,0.001970023,0.0009050245,0.0007712612,0.00005326991,0.0000203477,0.0008225183,0.00006440267,0.006706788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09716155,"threshold_uncertainty_score":0.9998005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008050685255940033,"score_gpt":0.2588054150301625,"score_spread":0.2507547297742224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}