{"id":"W4414382923","doi":"10.1111/apt.70378","title":"Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis","year":2025,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta; Institute of Infection and Immunity","funders":"Dr. Falk Pharma; National Institute for Health and Care Research; Intercept Pharmaceuticals","keywords":"Obeticholic acid; Discontinuation; Clinical trial; Primary biliary cirrhosis; Ursodeoxycholic acid; Biliary tract","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006510228,0.0001435748,0.0002799493,0.000355941,0.0002269786,0.0004849806,0.0001760121,0.0003216217,0.001585044],"category_scores_gemma":[0.003030986,0.0001211359,0.0003351411,0.0005454511,0.000243269,0.0002458561,0.0003135366,0.0003785339,0.000247616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002266722,"about_ca_system_score_gemma":0.000231955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008684703,"about_ca_topic_score_gemma":0.001486954,"domain_scores_codex":[0.9995182,0.0001365376,0.00008380238,0.00007269339,0.000109434,0.0000794407],"domain_scores_gemma":[0.9966311,0.0005929317,0.002089668,0.0001461214,0.0001867803,0.0003533778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003153707,0.0000191602,0.9980901,0.000008078289,0.00001739471,0.00007359846,0.00001990921,0.00002066873,0.0002815453,0.000003230245,0.00002062844,0.001130452],"study_design_scores_gemma":[0.000006014936,0.0001611628,0.99907,0.000003709418,0.00001252903,0.0004844261,0.00003808866,0.00006412268,0.00008902774,0.000006898961,0.00006250355,0.000001527978],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994986,0.000218787,0.00002841827,0.0000239083,0.000002233124,0.000002780274,0.00005842585,0.000001890037,0.0001648778],"genre_scores_gemma":[0.999768,0.0000530638,0.0000239466,0.000007359367,0.000004937731,0.000002009128,0.00008126225,5.849958e-7,0.00005889344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585044,"threshold_uncertainty_score":0.005302489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07602182644909838,"score_gpt":0.414160776554416,"score_spread":0.3381389501053176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}