{"id":"W4414383027","doi":"10.3390/antibiotics14090956","title":"Retargeting Gram-Positive-Only Adarotene-Derived Antibacterials to Broad-Spectrum Antibiotics","year":2025,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dell'Università e della Ricerca; Queen's University; European Commission","keywords":"Antibiotics; Membrane permeability; Colistin; Antibiotic resistance; Antimicrobial; Membrane; Membrane integrity; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004805085,0.0005823633,0.0006488293,0.0002223396,0.0003501003,0.0002512788,0.0007425537,0.0005067506,0.00004018592],"category_scores_gemma":[0.000643981,0.000606217,0.0002577841,0.0005866577,0.0002710582,0.00001878453,0.0005496088,0.0002453991,0.0001069454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006647688,"about_ca_system_score_gemma":0.0003837076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007360491,"about_ca_topic_score_gemma":0.0001669342,"domain_scores_codex":[0.9965873,0.0002040594,0.0008122469,0.001115601,0.000301235,0.000979497],"domain_scores_gemma":[0.997994,0.00007272536,0.0002641249,0.001176953,0.0002524233,0.0002397637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002528094,0.000149977,0.0711661,0.0001144578,0.000204124,0.00002867143,0.0000431442,0.00003227524,0.9204464,0.001090718,0.005554925,0.0009164194],"study_design_scores_gemma":[0.0006024214,0.0003220761,0.1361541,0.0003421943,0.00009053142,0.00002669978,0.0001157366,0.0000296224,0.8456918,0.0001420679,0.01583017,0.000652604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800515,0.0003747456,0.01223133,0.001262412,0.001512896,0.000723338,0.0001263417,0.0001053405,0.003612102],"genre_scores_gemma":[0.9813613,0.0006582214,0.01258599,0.001642209,0.0005336758,1.661234e-7,0.0003671381,0.00009563661,0.002755613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07475459,"threshold_uncertainty_score":0.9996389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006484683833365668,"score_gpt":0.258036297142741,"score_spread":0.2515516133093753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}