{"id":"W4414383027","doi":"10.3390/antibiotics14090956","title":"Retargeting Gram-Positive-Only Adarotene-Derived Antibacterials to Broad-Spectrum Antibiotics","year":2025,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dell'Università e della Ricerca; Queen's University; European Commission","keywords":"Antibiotics; Membrane permeability; Colistin; Antibiotic resistance; Antimicrobial; Membrane; Membrane integrity; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204061,0.0003264706,0.0002178757,0.0001089592,0.00008245265,0.0002337702,0.0002314716,0.0002885828,0.001135008],"category_scores_gemma":[0.0001369392,0.0001289605,0.0002345237,0.00005705756,0.000171972,0.0002211577,0.0001775409,0.0004811177,0.0003926455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119009,"about_ca_system_score_gemma":0.0001597624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001827992,"about_ca_topic_score_gemma":0.0003820107,"domain_scores_codex":[0.9999342,0.00001045043,0.000005385848,0.0000162461,0.00001904813,0.00001471643],"domain_scores_gemma":[0.9999409,0.00001262975,0.00002043764,0.000006435278,0.000008155875,0.00001159668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001140014,0.00007327224,0.0001033201,0.0001416969,0.000008325243,0.00009998865,0.00001640425,0.001251615,0.9944112,0.0003302927,0.00007362906,0.003376246],"study_design_scores_gemma":[0.00005361158,0.001273248,0.0004365798,0.00001808058,0.00002318418,0.0002139269,0.00001417173,0.00454506,0.9867651,0.00008774895,0.00655523,0.00001389317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828508,0.00333244,0.009601058,0.0001521131,0.00007434244,0.0001304966,0.0002240727,0.0001313349,0.00350331],"genre_scores_gemma":[0.9829451,0.002434829,0.01210053,0.000129871,0.00001897317,0.0000736918,0.0002171768,0.00002824226,0.0020516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135008,"threshold_uncertainty_score":0.003797054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006484683833365668,"score_gpt":0.258036297142741,"score_spread":0.2515516133093753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}