{"id":"W4414383439","doi":"10.1152/ajpcell.00471.2025","title":"Isolation of functional lysosomes from skeletal muscle","year":2025,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Skeletal muscle; Lysosome; Organelle; Mitochondrion; Autophagy; Function (biology); Myocyte; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000442701,0.0006632974,0.0004429422,0.0005985826,0.0004693703,0.0006155793,0.0004201853,0.0004235771,0.001438754],"category_scores_gemma":[0.000422547,0.0002884068,0.0004632034,0.0002271988,0.0002786687,0.0004093165,0.000590653,0.0008845596,0.001354349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000281576,"about_ca_system_score_gemma":0.0006161779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005959033,"about_ca_topic_score_gemma":0.00161825,"domain_scores_codex":[0.9997723,0.00003304226,0.0000350763,0.00005940006,0.00004834775,0.0000519055],"domain_scores_gemma":[0.9997465,0.00006189702,0.00003219297,0.00004059565,0.00006605002,0.00005280994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007160511,0.00002324888,0.0002273415,0.0001274885,0.000009780676,0.0001022312,0.00002355573,0.00006536124,0.9962829,0.0002795716,0.0001352415,0.002651815],"study_design_scores_gemma":[0.00005309773,0.0002396113,0.004585748,0.00005871428,0.00004518921,0.0007637885,0.00004732317,0.001317792,0.9816481,0.0002576596,0.01097017,0.0000128268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7256546,0.01649462,0.2366991,0.001511391,0.0005682128,0.001438811,0.005964178,0.0008034492,0.01086563],"genre_scores_gemma":[0.7874212,0.009593352,0.1715447,0.0007949654,0.000225722,0.001023688,0.01222513,0.000348127,0.01682299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438754,"threshold_uncertainty_score":0.004813135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006797273520678352,"score_gpt":0.2531584492986068,"score_spread":0.2463611757779284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}