{"id":"W4414385509","doi":"10.1038/s44276-025-00174-x","title":"Evaluating the significance of combining PD-L1 and TILs as biomarkers in non-small cell lung cancer patients treated with immunotherapy: a systematic review","year":2025,"lang":"en","type":"review","venue":"BJC Reports","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biomarker; Lung cancer; Overall survival; Predictive value; Immunotherapy; Tumor-infiltrating lymphocytes; Meta-analysis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007093838,0.001178467,0.01116515,0.007880654,0.0004464108,0.002533632,0.001737091,0.001643791,0.002577254],"category_scores_gemma":[0.02794744,0.000874899,0.00937373,0.008225164,0.0008717751,0.002017639,0.0012329,0.0009776363,0.0002286209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002371598,"about_ca_system_score_gemma":0.00555458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005004271,"about_ca_topic_score_gemma":0.01473292,"domain_scores_codex":[0.9939102,0.001957709,0.002697357,0.0005276729,0.0007740472,0.0001329372],"domain_scores_gemma":[0.971943,0.02016588,0.005336911,0.0003449548,0.001899808,0.0003093512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0005019979,0.00001541745,0.001297864,0.9417236,0.0268399,0.00006691735,0.0001043371,0.0001084763,0.0002190907,0.0001004888,0.0006228886,0.02839906],"study_design_scores_gemma":[0.0006534529,0.000425644,0.007220969,0.6818753,0.2961971,0.0003316474,0.0002067911,0.0001695242,0.0002883305,0.0003300783,0.01224834,0.00005272521],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00141591,0.9976914,0.0001180817,0.0001495291,0.00006322689,0.0001410237,0.0002790119,0.000005753929,0.0001359623],"genre_scores_gemma":[0.03165665,0.9662097,0.000544859,0.000626153,0.0001121797,0.0004411572,0.0003053972,0.000009128709,0.00009481341],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01116515,"threshold_uncertainty_score":0.03751624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02957072950078021,"score_gpt":0.3550188290732884,"score_spread":0.3254480995725082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}