{"id":"W4414392198","doi":"10.18632/oncotarget.28768","title":"Loss of <i>Trp53</i> results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma","year":2025,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Ovarian Cancer Canada; Occupational Cancer Research Centre; Western University","funders":"","keywords":"Serous carcinoma; Tumor microenvironment; Immune system; Ovarian carcinoma; Serous fluid; Phenotype; Disease; T cell; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002675974,0.0005632183,0.0004038681,0.0005356707,0.0002843607,0.0004942677,0.0003479143,0.0007138559,0.003944481],"category_scores_gemma":[0.0001794084,0.0003261002,0.0005316163,0.0002712107,0.0007247315,0.0003992369,0.0002367192,0.001532237,0.001736211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814655,"about_ca_system_score_gemma":0.0002807038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007120985,"about_ca_topic_score_gemma":0.0009094801,"domain_scores_codex":[0.9995585,0.00006544669,0.00006737592,0.00008723301,0.0001135462,0.0001078897],"domain_scores_gemma":[0.9996341,0.00003516053,0.0001287617,0.00004242245,0.00002327061,0.0001362059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004456023,0.0001189486,0.0003649724,0.00007590153,0.00001363729,0.0003616266,0.00004308568,0.0001010539,0.9957849,0.0002420136,0.0006734557,0.001774692],"study_design_scores_gemma":[0.000392039,0.002234874,0.01994013,0.0000540552,0.0001025699,0.003972171,0.0004092239,0.002823038,0.9543,0.0003856652,0.01534961,0.00003655678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856022,0.002163081,0.003017119,0.001134246,0.0003455382,0.00009403281,0.002462946,0.0004808067,0.004699944],"genre_scores_gemma":[0.9854282,0.001393746,0.001893337,0.000418732,0.0000813405,0.0001619579,0.001528481,0.0001636808,0.008930644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003944481,"threshold_uncertainty_score":0.01319563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183716393664959,"score_gpt":0.2581379820011611,"score_spread":0.2463008180645115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}