{"id":"W4414393465","doi":"10.1021/acs.bioconjchem.5c00326","title":"Novel Disulfide-Containing Linkages of Pyrimidine Nucleobases to Solid Supports: A Versatile Platform for Oligonucleotide Conjugation","year":2025,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Human Frontier Science Program; Canada Foundation for Innovation","keywords":"Linker; Oligonucleotide; Nucleic acid; Pyrimidine; Nucleobase; Conjugated system; Covalent bond","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001722239,0.0003689686,0.000491821,0.00004921211,0.0002099369,0.00006154463,0.000476369,0.0002864071,0.0007543587],"category_scores_gemma":[0.0005176232,0.0004121752,0.0002427126,0.0002801589,0.0001575958,0.0001167732,0.0001802648,0.0001986033,0.00001161098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000153511,"about_ca_system_score_gemma":0.0002046778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005160619,"about_ca_topic_score_gemma":0.000004850009,"domain_scores_codex":[0.9978738,0.000002403483,0.0008150699,0.0006469217,0.0001924639,0.0004693851],"domain_scores_gemma":[0.9980922,0.0003623571,0.0003357764,0.0007371518,0.000260976,0.0002115317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001650178,0.0002325686,0.0003886102,0.001322824,0.0001214091,0.000001410397,0.0001593077,0.00006733825,0.9933648,0.0005298381,0.002585112,0.001061797],"study_design_scores_gemma":[0.001411951,0.00002237897,0.00008272162,0.0004379284,0.0001176969,0.000006630595,0.001017546,0.0003296137,0.9680806,0.0004716483,0.02764838,0.0003728943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722711,0.00008741235,0.001850908,0.0008121533,0.00006544244,0.0003847347,0.001141598,0.0002120836,0.0231746],"genre_scores_gemma":[0.9927974,0.00002394877,0.00193522,0.00026537,0.0002334349,0.0004294215,0.0008167005,0.00004669516,0.003451853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02528416,"threshold_uncertainty_score":0.999833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027431080823359,"score_gpt":0.2953068170402531,"score_spread":0.2750325062320195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}