{"id":"W4414394595","doi":"10.1242/dmm.052634","title":"FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation","year":2025,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Brain Tumour Charity; University of Edinburgh; Institute of Genetics; Cancer Research UK","keywords":"Citric acid cycle; Focal adhesion; Glycolysis; Glutamine; Anaerobic glycolysis; Mitochondrion; Bioenergetics; Kinase; Warburg effect; Mechanotransduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004896936,0.0001900663,0.0001135326,0.0001584802,0.000132657,0.0002647129,0.00007988587,0.0001182352,0.0007038292],"category_scores_gemma":[0.00005464574,0.00006243262,0.0001186242,0.0001036892,0.0001349524,0.0001284959,0.0001561003,0.0001895108,0.0001114314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872602,"about_ca_system_score_gemma":0.0001992072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006502542,"about_ca_topic_score_gemma":0.001415032,"domain_scores_codex":[0.9999466,0.000008880083,0.000003456505,0.000007015538,0.00001056957,0.00002339445],"domain_scores_gemma":[0.9999771,0.000001499914,0.000008770945,0.000001431381,0.000002768468,0.000008387673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000553484,0.00004706952,0.001473981,0.00007290421,0.00001287499,0.0001015067,0.0000320016,0.0002478598,0.9913264,0.0004665256,0.0002044454,0.0054608],"study_design_scores_gemma":[0.00007829907,0.0006866825,0.06496596,0.00002214968,0.00006188582,0.0002259434,0.0002007707,0.003163549,0.9244771,0.0004340039,0.005668149,0.00001558605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968936,0.001123012,0.0004279011,0.0001151664,0.00001839876,0.000008180018,0.0001410887,0.00002620976,0.001246331],"genre_scores_gemma":[0.998609,0.0005019561,0.0001299029,0.00002181305,0.000003221667,0.000009116214,0.00006871898,0.000002638393,0.0006536342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007038292,"threshold_uncertainty_score":0.002354562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003857081553087755,"score_gpt":0.1954489491470097,"score_spread":0.1915918675939219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}