{"id":"W4414400861","doi":"10.1212/wnl.0000000000213977","title":"Toward a Unified Definition of Progression Independent of Relapse Activity in Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica; Ministero della Salute; Multiple Sclerosis Society of Canada; Alexion Pharmaceuticals; Horizon Therapeutics; Teva Pharmaceutical Industries; Celgene; Biogen; Fondazione Italiana Sclerosi Multipla; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Sanofi; National Multiple Sclerosis Society","keywords":"Multiple sclerosis; Predictive value; Clinical Practice; Value (mathematics); MEDLINE","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03407384,0.001445416,0.002008375,0.009830263,0.0006504197,0.003355757,0.001828496,0.001318655,0.0006788909],"category_scores_gemma":[0.04854612,0.0004347329,0.001842404,0.004268761,0.00170729,0.003164775,0.003927876,0.002094838,0.0003978877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009201242,"about_ca_system_score_gemma":0.002256625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002640964,"about_ca_topic_score_gemma":0.002064028,"domain_scores_codex":[0.984593,0.009180999,0.002447888,0.0015012,0.001808211,0.0004686133],"domain_scores_gemma":[0.9655942,0.01742869,0.01001334,0.001904803,0.004042753,0.001016304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009390956,0.0001960517,0.9123803,0.0009415357,0.0005904141,0.0002097851,0.0009552329,0.00373672,0.001218788,0.003204965,0.002490786,0.07313634],"study_design_scores_gemma":[0.0002509509,0.001879135,0.9482832,0.001181477,0.0007172054,0.002435778,0.001247047,0.02384161,0.001141672,0.00994765,0.008890607,0.000183628],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8688583,0.03068251,0.08303169,0.002820554,0.0005021566,0.001112906,0.006913605,0.0005649092,0.005513418],"genre_scores_gemma":[0.945736,0.001272718,0.04705634,0.0003219165,0.0004633337,0.0006561371,0.004189693,0.00005932838,0.0002445932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03407384,"threshold_uncertainty_score":0.1802019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1325289137154619,"score_gpt":0.3375931805432487,"score_spread":0.2050642668277868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}