{"id":"W4414402903","doi":"10.1016/j.jbc.2025.110751","title":"SAG1.3-derived Frizzled-targeting small-molecule compounds","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020; Innovative Medicines Initiative; Emil och Wera Cornells Stiftelse; Stiftelsen Lars Hiertas Minne; Science for Life Laboratory; Vetenskapsrådet; Kungliga Tekniska Högskolan; Karolinska Institutet; Novo Nordisk Fonden; Svenska Sällskapet för Medicinsk Forskning; Wenner-Gren Stiftelserna; Cancerfonden; Deutsche Forschungsgemeinschaft; Robert Bosch Stiftung; European Commission; Alex och Eva Wallströms Stiftelse för Vetenskaplig Forskning och Utbildning; Wenner-Gren Foundation; European Federation of Pharmaceutical Industries and Associations; Ontario Institute for Cancer Research; Novo Nordisk; Diamond Light Source; McGill University","keywords":"Wnt signaling pathway; LGR5; HEK 293 cells; Receptor; Embryonic stem cell; Regulator; Signal transduction; Cell; Viability assay","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456529,0.0001152299,0.0003842644,0.00004749189,0.00005875935,0.00001889853,0.0001086703,0.0001616406,0.0006520709],"category_scores_gemma":[0.0004665889,0.00007617999,0.0003427119,0.0002008954,0.00009233834,0.00001872116,0.00004417859,0.0003855836,0.000005869655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006181492,"about_ca_system_score_gemma":0.00008764183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001091644,"about_ca_topic_score_gemma":1.005517e-7,"domain_scores_codex":[0.9990776,0.00002790137,0.0004764108,0.0001299915,0.0001267644,0.0001613633],"domain_scores_gemma":[0.9992494,0.00007656778,0.0002237703,0.0001020413,0.0002056661,0.0001425291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185751,0.0001610755,0.004277639,0.00004556482,0.0001215483,0.0001461963,0.000008279956,0.000001610728,0.9913302,0.000006964666,0.003556112,0.0002262566],"study_design_scores_gemma":[0.001192343,0.00009451227,0.002193009,0.0004549895,0.0000920737,0.0001561046,0.0002395404,0.00006083887,0.9921293,0.0001506137,0.00313857,0.0000981062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775649,0.0004058489,0.0005987005,0.002218222,0.00002364036,0.00002671227,0.00000255951,0.00002174158,0.01913773],"genre_scores_gemma":[0.9963916,0.00006519975,0.001050944,0.001253453,0.0002329374,9.798705e-7,0.0000187385,0.000003657441,0.0009824731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01882677,"threshold_uncertainty_score":0.7139719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02324165042005534,"score_gpt":0.2779185561662884,"score_spread":0.2546769057462331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}