{"id":"W4414404323","doi":"10.1136/bmjopen-2025-100889","title":"Canadian real-world hybrid longitudinal cohort study of treatment discontinuations and modifications for patients with HER2+ and HER2-low metastatic breast cancer on trastuzumab deruxtecan enrolled in a patient support programme: the HER-TEMPO study protocol","year":2025,"lang":"en","type":"article","venue":"BMJ Open","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada); University of Toronto; EVERSANA (Canada); Mount Sinai Hospital","funders":"Daiichi Sankyo Europe; AstraZeneca Canada; AstraZeneca","keywords":"Metastatic breast cancer; Trastuzumab; Breast cancer; Cohort study; Cohort; Epidemiology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005263556,0.001481241,0.001138113,0.001140074,0.003488175,0.001916115,0.003278251,0.001775674,0.00556312],"category_scores_gemma":[0.008759632,0.001012769,0.002255532,0.004445929,0.001145915,0.0007975568,0.001887093,0.002352512,0.001024263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02623154,"about_ca_system_score_gemma":0.05427438,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8740165,"about_ca_topic_score_gemma":0.9309399,"domain_scores_codex":[0.9959677,0.0009765817,0.0004236046,0.0008281852,0.0009259693,0.0008779225],"domain_scores_gemma":[0.9912431,0.0005379181,0.001954088,0.0009931065,0.003665152,0.00160657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0210333,0.001196851,0.9121394,0.001716879,0.004131101,0.0003294477,0.001791126,0.001244496,0.0003791441,0.002013003,0.03971136,0.01431401],"study_design_scores_gemma":[0.007622079,0.001539911,0.9534754,0.000805716,0.001863021,0.0002186368,0.001418412,0.001586646,0.000169251,0.0005310679,0.03052846,0.0002414775],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7021022,0.005066557,0.002190717,0.003084474,0.0002910139,0.02734164,0.2479096,0.00008906281,0.01192471],"genre_scores_gemma":[0.8708274,0.002222829,0.004774953,0.002121523,0.0001575902,0.02014854,0.09551763,0.00004299194,0.004186634],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.1259835,"threshold_uncertainty_score":0.2534508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07744423486717573,"score_gpt":0.4562676566616243,"score_spread":0.3788234217944486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}