{"id":"W4414409029","doi":"10.1080/17576180.2025.2554565","title":"Upgrading nucleic acid and antisense therapeutics: challenges, solutions, and future directions","year":2025,"lang":"en","type":"review","venue":"Bioanalysis","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"","keywords":"Druggability; Oligonucleotide; Nuclease; Nucleic acid; RNA; RNA interference; Gene silencing; Antisense therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001357263,0.0003065089,0.0006795364,0.0002432136,0.0001908223,0.00005555122,0.000134344,0.0003928226,0.00001050018],"category_scores_gemma":[0.00001477617,0.0002562474,0.0003531527,0.0002227864,0.00008453715,0.00000365211,0.0001545077,0.0001380812,0.000005212655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000167441,"about_ca_system_score_gemma":0.00008250457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001291899,"about_ca_topic_score_gemma":0.00006445018,"domain_scores_codex":[0.9987488,0.0001363167,0.0002740599,0.0005561408,0.00007184558,0.0002128455],"domain_scores_gemma":[0.9993278,0.00002048904,0.0001270467,0.0004040382,0.00005580594,0.0000647846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002318269,0.00001697907,0.000005208367,0.001071955,0.001157559,0.000002417126,0.00001835247,1.78302e-8,0.0001040414,0.00005051427,0.0001239853,0.9974467],"study_design_scores_gemma":[0.00006172777,0.00004458979,0.00001554368,0.000631819,0.002581784,0.00002737166,0.00009667159,0.000005288723,0.00002893391,0.00001181095,0.9962364,0.0002580597],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000783555,0.9988174,0.00001849102,0.0001966848,0.0001741976,0.00014081,0.00007979174,0.00001475886,0.0004795199],"genre_scores_gemma":[0.0002561008,0.9982808,0.0001022274,0.00005879081,0.0004122579,0.00003019757,0.0001504188,0.00002000322,0.0006891979],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9971886,"threshold_uncertainty_score":0.999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03962771389513007,"score_gpt":0.3018475452170213,"score_spread":0.2622198313218913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}