{"id":"W4414409029","doi":"10.1080/17576180.2025.2554565","title":"Upgrading nucleic acid and antisense therapeutics: challenges, solutions, and future directions","year":2025,"lang":"en","type":"review","venue":"Bioanalysis","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"","keywords":"Druggability; Oligonucleotide; Nuclease; Nucleic acid; RNA; RNA interference; Gene silencing; Antisense therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001091808,0.000781772,0.0009316297,0.001291445,0.0003416085,0.001257991,0.0007980209,0.001442292,0.004134023],"category_scores_gemma":[0.0008257531,0.0003314217,0.0004517712,0.001303925,0.0006731651,0.002584053,0.000854033,0.002754835,0.001786687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008680981,"about_ca_system_score_gemma":0.001671104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009590462,"about_ca_topic_score_gemma":0.00211086,"domain_scores_codex":[0.9996637,0.00006709363,0.00003296113,0.0000486754,0.0001376165,0.00004992251],"domain_scores_gemma":[0.9996293,0.0001858247,0.00004032247,0.0000122962,0.00009241972,0.0000398127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005432216,0.00009879428,0.0001026892,0.01530904,0.00004090972,0.0002519028,0.0001356465,0.000861738,0.007086348,0.02110974,0.02925962,0.9256892],"study_design_scores_gemma":[0.000008474042,0.00007843164,0.0001807631,0.001870806,0.00002986711,0.0005221257,0.00008973899,0.0001496942,0.0009687362,0.0053508,0.9907356,0.00001483928],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002282873,0.9956333,0.000555059,0.001035294,0.000422485,0.00000639894,0.00001343447,0.0000147395,0.002090959],"genre_scores_gemma":[0.001061653,0.9962932,0.0006723237,0.000507348,0.0002165604,0.00001031634,0.00002147932,0.000002975139,0.001214016],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004134023,"threshold_uncertainty_score":0.01382971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03962771389513007,"score_gpt":0.3018475452170213,"score_spread":0.2622198313218913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}