{"id":"W4414417409","doi":"10.21203/rs.3.rs-7543827/v1","title":"New proteomic signature in circulating extracellular vesicles from tumor-draining and peripheral veins of patients with lung adenocarcinoma","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Ligue Contre le Cancer","keywords":"Lung cancer; Adenocarcinoma; Lung; Downregulation and upregulation; Proteomics; Proteome; Extracellular; Extracellular vesicle; Biomarker","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011131,0.0001838461,0.0003383034,0.0004930776,0.0001840373,0.000673948,0.0001476343,0.0003972195,0.001261047],"category_scores_gemma":[0.000844162,0.0001073876,0.0001883546,0.000402221,0.0001297617,0.0002976135,0.000284042,0.0003090889,0.0002401838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110881,"about_ca_system_score_gemma":0.00009301874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000423408,"about_ca_topic_score_gemma":0.0003043538,"domain_scores_codex":[0.999879,0.00001916261,0.00001323472,0.00003879786,0.00002115039,0.0000286878],"domain_scores_gemma":[0.9997385,0.00007763274,0.00006943091,0.00001462307,0.00004130466,0.00005839848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002135141,0.00005716276,0.9269342,0.00006880149,0.0001221708,0.00135003,0.0002920901,0.0001155903,0.05493416,0.0001213184,0.0004253887,0.01344392],"study_design_scores_gemma":[0.00002060785,0.0001713979,0.990957,0.00001102552,0.00007857796,0.002935987,0.0003330719,0.0005748308,0.003995615,0.0001841271,0.0007283193,0.000009350458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987023,0.0003927378,0.0001930568,0.0000380076,0.00001122363,0.000004159802,0.0002830062,0.000005982083,0.0003695274],"genre_scores_gemma":[0.999071,0.0001178277,0.0001271544,0.00003436606,0.00002148089,0.000005197919,0.000372602,0.000005220612,0.0002451717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261047,"threshold_uncertainty_score":0.004218638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491562191125562,"score_gpt":0.2996746830353552,"score_spread":0.2847590611240996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}