{"id":"W4414418464","doi":"10.1136/egastro-2024-100106","title":"Immunotherapy against colorectal cancer via delivery of anti-PD-L1 nanobody mRNA","year":2025,"lang":"en","type":"letter","venue":"eGastroenterology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; University of Hawai'i; American Cancer Society","keywords":"Immunotherapy; Colorectal cancer; Messenger RNA; Cancer immunotherapy; Cancer; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101148,0.0002508541,0.000227429,0.000216108,0.00008661496,0.0002118157,0.0001405088,0.0002364048,0.0007054035],"category_scores_gemma":[0.00006598044,0.00007798354,0.0001630086,0.00008161056,0.0002130705,0.0001367576,0.0001253986,0.0005128055,0.0002352163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695293,"about_ca_system_score_gemma":0.000192266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002778057,"about_ca_topic_score_gemma":0.0003430126,"domain_scores_codex":[0.9999127,0.00001031181,0.000006020458,0.00002310071,0.00002619201,0.00002148767],"domain_scores_gemma":[0.9999585,0.000007850196,0.00001363702,0.000004258563,0.000005564547,0.00001019944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008328041,0.00006528799,0.0001213482,0.00006099879,0.000003932888,0.00002003703,0.00001216379,0.0001630356,0.995507,0.0001157461,0.00007130562,0.003775879],"study_design_scores_gemma":[0.00005289483,0.001550142,0.001092855,0.000008453485,0.00002706994,0.0001663879,0.00001243448,0.00125489,0.9903247,0.00004479469,0.00546069,0.000004595501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885245,0.003188466,0.005859171,0.0002295917,0.00007841124,0.00009135705,0.0001868257,0.0001834937,0.001658224],"genre_scores_gemma":[0.99261,0.001393212,0.003468693,0.00008834383,0.00002982766,0.00009141752,0.0002079732,0.00001618992,0.002094334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007054035,"threshold_uncertainty_score":0.002359748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301601861863046,"score_gpt":0.2918407181757531,"score_spread":0.2788246995571227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}