{"id":"W4414418464","doi":"10.1136/egastro-2024-100106","title":"Immunotherapy against colorectal cancer via delivery of anti-PD-L1 nanobody mRNA","year":2025,"lang":"en","type":"letter","venue":"eGastroenterology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; University of Hawai'i; American Cancer Society","keywords":"Immunotherapy; Colorectal cancer; Messenger RNA; Cancer immunotherapy; Cancer; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001623625,0.0005082375,0.001434872,0.0005252855,0.00009162528,0.00001330926,0.0004779052,0.0007711421,0.0008770202],"category_scores_gemma":[0.00001901064,0.0004263131,0.0005600335,0.0002010411,0.0005380208,0.00004365995,0.0002348124,0.002160183,0.00004515795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001498713,"about_ca_system_score_gemma":0.000308323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009062056,"about_ca_topic_score_gemma":0.0000679866,"domain_scores_codex":[0.9968511,0.0002524054,0.0007203654,0.0006307791,0.0005651196,0.0009801768],"domain_scores_gemma":[0.9986686,0.0001568826,0.0003050542,0.0004432254,0.0003220046,0.0001042272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003532597,0.0001954738,0.08061338,0.0007647086,0.001734169,0.001241338,0.0000741571,0.00000589106,0.05820572,0.000003445344,0.8493982,0.004230933],"study_design_scores_gemma":[0.003492558,0.002478024,0.06021737,0.0006649171,0.0002381175,0.0003007199,0.0000127371,0.0001389922,0.007510371,0.00002719148,0.9246175,0.000301557],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6731068,0.001606272,0.00004325355,0.3219061,0.001126271,0.0005511221,0.0004315791,0.00004255626,0.001186057],"genre_scores_gemma":[0.1394797,0.00617355,0.0004093338,0.8303968,0.003889944,0.0001811267,0.001704961,0.0001160804,0.01764853],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5336271,"threshold_uncertainty_score":0.9998189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301601861863046,"score_gpt":0.2918407181757531,"score_spread":0.2788246995571227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}