{"id":"W4414420350","doi":"10.1002/alz.70689","title":"The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; McGill University","funders":"Eisai Incorporated; Fonds de Recherche du Québec - Santé; GHR Foundation; Canadian Institutes of Health Research; F. Hoffmann-La Roche; Avid Radiopharmaceuticals; Korea Health Industry Development Institute; Deutsches Zentrum für Neurodegenerative Erkrankungen; Japan Agency for Medical Research and Development; Fondation Brain Canada; Eli Lilly and Company; Fleni; National Institute on Aging; Alzheimer's Association","keywords":"Tau pathology; Tau protein; Disease; Immunotherapy; Amyloid (mycology); Amyloid β","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001465157,0.0003184844,0.0004130325,0.0002507604,0.0001640595,0.0004697355,0.0002140328,0.0003496422,0.001726592],"category_scores_gemma":[0.001765242,0.0001646395,0.0003348473,0.0002364718,0.0002926652,0.0003435356,0.000230757,0.0005269006,0.0002280203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003019227,"about_ca_system_score_gemma":0.000276637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002772739,"about_ca_topic_score_gemma":0.0003850952,"domain_scores_codex":[0.9996691,0.0001066376,0.00003205419,0.00007107797,0.00008246202,0.00003874631],"domain_scores_gemma":[0.9987434,0.0003346151,0.0005031528,0.00009534873,0.0001436678,0.0001798986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1792753,0.002771165,0.5181492,0.001136138,0.003618416,0.0003193623,0.0002883012,0.0009577732,0.1583187,0.0001785273,0.001089582,0.1338976],"study_design_scores_gemma":[0.001396952,0.02981671,0.9450466,0.0000526954,0.001166222,0.0006427112,0.00007660098,0.0006928722,0.01882416,0.0003895509,0.001874158,0.00002080371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943653,0.004476564,0.0002287314,0.00005957313,0.00001679137,0.00004074846,0.0001910488,0.000008961772,0.0006122382],"genre_scores_gemma":[0.9986125,0.0005047517,0.0002694793,0.00004052559,0.00001865996,0.00004111709,0.0001940939,0.000003577693,0.0003152314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001726592,"threshold_uncertainty_score":0.007748604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03333296447731162,"score_gpt":0.298660638361143,"score_spread":0.2653276738838314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}