{"id":"W4414428345","doi":"10.1261/rna.080559.125","title":"Depurination of sarcin/ricin loop 25S rRNA is signaled through the small ribosomal subunit during translation","year":2025,"lang":"en","type":"article","venue":"RNA","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Depurination; Ribosome; Ribosomal RNA; Eukaryotic Ribosome; Eukaryotic Large Ribosomal Subunit; Eukaryotic Small Ribosomal Subunit; 5.8S ribosomal RNA; RNA; Transfer RNA; Elongation factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130545,0.0003140027,0.0001963739,0.0001164778,0.00008242835,0.000192009,0.0001222663,0.0001440055,0.0004292637],"category_scores_gemma":[0.00009630377,0.0001108608,0.0002103142,0.00009740385,0.0001479422,0.0001187291,0.0001194858,0.0002194925,0.0002461282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775265,"about_ca_system_score_gemma":0.000118576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004332241,"about_ca_topic_score_gemma":0.0006258899,"domain_scores_codex":[0.999878,0.00001404347,0.00001014965,0.00003752948,0.00003713695,0.00002304718],"domain_scores_gemma":[0.9999086,0.00001075781,0.0000412172,0.00001316713,0.00001197913,0.00001436923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000229178,0.000003256151,0.0001493978,0.00001017476,0.000001989223,0.00001592272,0.000004003828,0.00001645806,0.9994654,0.00002036139,0.0000067674,0.0002834329],"study_design_scores_gemma":[0.000001844052,0.00005098139,0.005295774,0.000002060771,0.000006421103,0.00007502761,0.000008505614,0.000346704,0.9934844,0.00001691655,0.0007095712,0.000001693983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966295,0.001076178,0.001580072,0.00003795621,0.00001219989,0.000006694222,0.0001594148,0.00005995373,0.0004379454],"genre_scores_gemma":[0.99653,0.0004730736,0.001214714,0.00002641692,0.000005820054,0.000009399547,0.0003795239,0.0000165586,0.001344538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004332241,"threshold_uncertainty_score":0.002013564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817552316961467,"score_gpt":0.2388118620009513,"score_spread":0.2206363388313366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}