{"id":"W4414438945","doi":"10.1093/bjd/ljaf285","title":"Efficacy and safety of lebrikizumab in adult and adolescent patients with moderate-to-severe atopic dermatitis inadequately controlled with or ineligible for ciclosporin A: a placebo-controlled, randomized phase IIIb clinical study (ADvantage)","year":2025,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Manchester Biomedical Research Centre","keywords":"Ciclosporin; Atopic dermatitis; Clinical study; Randomized controlled trial; Clinical trial; Signs and symptoms; Safety profile","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001898959,0.0007169422,0.001639702,0.0002303854,0.0002873188,0.0006068023,0.000482064,0.0009190124,0.003495754],"category_scores_gemma":[0.001282759,0.0004333522,0.001180179,0.0002121502,0.0006050501,0.0005388231,0.0002694679,0.001616559,0.0004280425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005417335,"about_ca_system_score_gemma":0.0009369414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004027535,"about_ca_topic_score_gemma":0.0009788782,"domain_scores_codex":[0.9994277,0.0002989402,0.00005925129,0.00008742371,0.0000599224,0.0000666971],"domain_scores_gemma":[0.999082,0.000245599,0.000259774,0.0000495431,0.00006919117,0.0002938896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9229925,0.01762213,0.01193013,0.0008871367,0.001052208,0.0001183772,0.00009553594,0.0002906504,0.00969814,0.0001104757,0.001055226,0.03414748],"study_design_scores_gemma":[0.742795,0.2330764,0.02040032,0.00005986772,0.0007213651,0.0002026043,0.00005088603,0.0005239994,0.000996244,0.00008340292,0.001074929,0.00001495155],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994267,0.003430139,0.0001674399,0.0002043782,0.00007087972,0.0009857169,0.0003214228,0.00001800719,0.0005348622],"genre_scores_gemma":[0.9957669,0.001348531,0.0005641688,0.0004126987,0.0001670083,0.0009254114,0.0003724638,0.000004716473,0.000438162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003495754,"threshold_uncertainty_score":0.01169443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054250624232542,"score_gpt":0.3139650421391255,"score_spread":0.3034225358968001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}