{"id":"W4414440271","doi":"10.1016/j.jhepr.2025.101596","title":"Development of a CRE/CREB-driven HBx responsive HBV cell culture reporter system for antiviral drug evaluation","year":2025,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Gilead Sciences; GlaxoSmithKline","keywords":"HBx; cccDNA; Hepatitis B virus; Antiviral drug; Drug development; Cell culture; DNA; Chronic hepatitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007336029,0.0005854621,0.0007096197,0.0005298268,0.0002874358,0.000553664,0.0007471553,0.0007449597,0.002482751],"category_scores_gemma":[0.0003668649,0.0003938755,0.0005857931,0.0003622696,0.0003532323,0.0004132493,0.0003041368,0.00131793,0.001461415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004912086,"about_ca_system_score_gemma":0.0004926975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007488704,"about_ca_topic_score_gemma":0.001133137,"domain_scores_codex":[0.9993367,0.0001035454,0.00006721306,0.0001307923,0.0002848781,0.000076918],"domain_scores_gemma":[0.9997357,0.00005556147,0.00005170257,0.00003946697,0.00008034034,0.00003730853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006983319,0.0000445297,0.00006121327,0.0000844206,0.000006412004,0.00002494502,0.00001733905,0.0001259501,0.9966009,0.0001981376,0.0001465903,0.002619766],"study_design_scores_gemma":[0.00002436326,0.0001978049,0.0002378036,0.000008792447,0.00001514957,0.0001032429,0.00001014925,0.001436551,0.9938975,0.00003272306,0.004026914,0.000008994691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5118441,0.005193489,0.4575518,0.0009943484,0.0007043902,0.002477805,0.008371341,0.002841688,0.01002105],"genre_scores_gemma":[0.6434566,0.00460765,0.3153285,0.0004414121,0.0001090429,0.003456181,0.01208071,0.0003376375,0.02018219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002482751,"threshold_uncertainty_score":0.008305609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02394264735160335,"score_gpt":0.3257353504875284,"score_spread":0.301792703135925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}