{"id":"W4414444667","doi":"10.1177/25424823251379878","title":"Neurofilament light (NfL) chain levels predict clinical decline in Alzheimer's disease: A systematic review and meta-analysis","year":2025,"lang":"en","type":"review","venue":"Journal of Alzheimer s Disease Reports","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; EVERSANA (Canada)","funders":"TauRx Pharmaceuticals","keywords":"Biomarker; Disease; Population; Context (archaeology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01378975,0.002811006,0.01764785,0.005822573,0.0007020128,0.002996706,0.002320085,0.002138096,0.003181197],"category_scores_gemma":[0.03239092,0.001519116,0.03696729,0.007509888,0.0007475933,0.001579181,0.001531664,0.001677003,0.0003323238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002399366,"about_ca_system_score_gemma":0.004088602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009056129,"about_ca_topic_score_gemma":0.02056056,"domain_scores_codex":[0.9918336,0.003581379,0.002364971,0.001109806,0.0008290932,0.0002812456],"domain_scores_gemma":[0.9763392,0.01784508,0.003362195,0.0006392536,0.001570737,0.0002433778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001340067,0.00002383078,0.007542762,0.3660602,0.6124383,0.0001246188,0.00007972569,0.0005771517,0.0001922807,0.0001048472,0.000715523,0.01080072],"study_design_scores_gemma":[0.0003066043,0.0001219163,0.004454515,0.0200571,0.9736773,0.00007533148,0.00003077334,0.000137186,0.00007043577,0.0001139486,0.0009378195,0.0000171342],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006076335,0.9918197,0.0005230329,0.0001967254,0.00009702726,0.0002411852,0.0007902082,0.0000267248,0.0002290173],"genre_scores_gemma":[0.1989407,0.7941528,0.00251638,0.0009358312,0.0002594789,0.001392297,0.001441775,0.00003422312,0.0003264866],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01764785,"threshold_uncertainty_score":0.07292801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1345802985771497,"score_gpt":0.448552702821203,"score_spread":0.3139724042440533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}