{"id":"W4414452576","doi":"10.1136/bmjopen-2025-105459","title":"Randomised controlled study investigating standard dose continuous renal replacement therapy (CRRT) versus low-dose CRRT in critically ill patients with acute kidney injury (AKI): study protocol for a prospective, randomised, controlled, international, multicentre trial (the ‘Ketzerei’ trial)","year":2025,"lang":"en","type":"article","venue":"BMJ Open","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Acute kidney injury; Renal replacement therapy; Critically ill; Protocol (science); Kidney disease; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01463704,0.005390055,0.01182985,0.001021319,0.001399465,0.003082373,0.002634993,0.006022112,0.03269957],"category_scores_gemma":[0.01403693,0.001817585,0.004775809,0.001722738,0.003500339,0.003024264,0.0014291,0.004362187,0.005328327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002406061,"about_ca_system_score_gemma":0.005892831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104433,"about_ca_topic_score_gemma":0.001945358,"domain_scores_codex":[0.9905466,0.005161682,0.001141176,0.001242262,0.0008308064,0.001077464],"domain_scores_gemma":[0.9942695,0.001410965,0.001640857,0.0008285787,0.0008231988,0.001026969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9885823,0.002751976,0.0002756241,0.002814705,0.001002099,0.00003824726,0.00004929646,0.0002383197,0.000645821,0.0003125605,0.000824448,0.002464626],"study_design_scores_gemma":[0.9805866,0.01581564,0.0004799392,0.0002350802,0.0005343441,0.00001518657,0.00001729099,0.0001981255,0.0001332477,0.0002927527,0.00167025,0.00002154169],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.06632197,0.003582228,0.003243593,0.000955128,0.00179983,0.9172322,0.003969504,0.0002086632,0.002686847],"genre_scores_gemma":[0.0520216,0.001363885,0.004092824,0.001252823,0.0003938169,0.9374272,0.001230335,0.00002430398,0.002193336],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03269957,"threshold_uncertainty_score":0.1093909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05191870797466102,"score_gpt":0.4525103000145176,"score_spread":0.4005915920398566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}