{"id":"W4414453020","doi":"10.1016/j.freeradbiomed.2025.09.029","title":"Accumulation of succinate in the blood is a potential early indicator of metabolic dysfunction-associated steatotic liver disease (MASLD)","year":2025,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; McGill University; Ste. Anne's Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Succinate dehydrogenase; Fructose; Extracellular; Mitochondrion; Metabolism; Liver disease; Peroxisome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003922393,0.0008153112,0.0005837721,0.00186811,0.0003145723,0.0006016008,0.0002531648,0.0005994719,0.001487522],"category_scores_gemma":[0.0007421665,0.0002858432,0.0003035818,0.001012162,0.0003603995,0.0004636117,0.0004275603,0.000792336,0.0003507774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000283508,"about_ca_system_score_gemma":0.0002626001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009687482,"about_ca_topic_score_gemma":0.001345939,"domain_scores_codex":[0.9997445,0.00006319769,0.00003246834,0.00003899286,0.00007887463,0.00004206675],"domain_scores_gemma":[0.9993054,0.00009500743,0.0003278868,0.00002803173,0.0001078821,0.0001358779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009979785,0.0004122095,0.6802732,0.0004395008,0.0002688188,0.003424937,0.0002154535,0.0002750786,0.272293,0.0004233807,0.000551693,0.0314429],"study_design_scores_gemma":[0.00008446413,0.003748436,0.8142895,0.0001479573,0.0002805695,0.007972311,0.0004727568,0.002331739,0.1666086,0.0009906366,0.003019857,0.00005328234],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796865,0.01105848,0.004087141,0.0003088294,0.000103281,0.00008285772,0.001383653,0.0001394753,0.003149722],"genre_scores_gemma":[0.9945077,0.001755244,0.002041595,0.0001013523,0.00004531506,0.00002328079,0.0007135226,0.00001190412,0.0008001006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186811,"threshold_uncertainty_score":0.004976273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906895844697368,"score_gpt":0.307363936038609,"score_spread":0.2882949775916353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}