{"id":"W4414453965","doi":"10.1101/2025.09.19.25336192","title":"Optimal cutoff, cognitive impairment diagnostic performance, reliability and concurrent validity of the Ascertaining Dementia 8 (AD8) questionnaire among Latinos","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Alzheimer's Association","keywords":"Concurrent validity; Dementia; Reliability (semiconductor); Youden's J statistic; Receiver operating characteristic; Cognition; Cognitive impairment; Clinical Dementia Rating; Cutoff","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009501635,0.0003567839,0.0005851868,0.002216393,0.0004707421,0.001073275,0.0004027839,0.0005445103,0.0007975199],"category_scores_gemma":[0.01751916,0.0002610892,0.0004293568,0.0008922839,0.0006032406,0.0006631719,0.0008368085,0.0003022991,0.0002786729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000602595,"about_ca_system_score_gemma":0.0006324128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003443066,"about_ca_topic_score_gemma":0.00324967,"domain_scores_codex":[0.9963549,0.002017499,0.0005357942,0.0003816636,0.0004175086,0.0002926456],"domain_scores_gemma":[0.9959742,0.001592015,0.001006525,0.0002647752,0.0009221683,0.00024031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006947764,0.000210077,0.9851344,0.00004994122,0.00005238474,0.0001595017,0.0009985726,0.0001782218,0.0008094066,0.0001910917,0.0003013105,0.01122027],"study_design_scores_gemma":[0.0001602112,0.0007506488,0.9909762,0.0001287785,0.00008374247,0.0005685909,0.002058505,0.001837238,0.001117995,0.0006864267,0.001602415,0.00002942594],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997245,0.0003756778,0.0007751451,0.00008696116,0.00001279607,0.00007851702,0.0002202545,0.00001207151,0.001193621],"genre_scores_gemma":[0.9965999,0.0001338931,0.002502148,0.00005385679,0.00001268558,0.000217679,0.0002997477,0.000006115069,0.0001740491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009501635,"threshold_uncertainty_score":0.05025005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247049980297337,"score_gpt":0.3144386899962688,"score_spread":0.2919681901932955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}