{"id":"W4414465149","doi":"10.1158/2326-6074.cimm25-b014","title":"Abstract B014: SYNCRIP drives therapy resistance via ferroptosis suppression and metabolic activation in Glioblastoma","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Downregulation and upregulation; Glioblastoma; Reprogramming; Cancer; Regulator; Cancer cell; Immunotherapy; Mechanism (biology)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012603,0.0002209556,0.0002797065,0.0003391698,0.0001766169,0.000318251,0.0001430225,0.0002762851,0.003032877],"category_scores_gemma":[0.00007798927,0.0001057477,0.0001842376,0.0002405881,0.0002639206,0.0001164759,0.0001847423,0.0004831404,0.0006596762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004958114,"about_ca_system_score_gemma":0.0003620661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127474,"about_ca_topic_score_gemma":0.001763788,"domain_scores_codex":[0.9998976,0.00001488967,0.000008163513,0.00001837607,0.00002945325,0.00003154218],"domain_scores_gemma":[0.9999193,0.000005426694,0.00002556386,0.000006856164,0.0000133125,0.00002954434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005576604,0.00008807307,0.001659806,0.00008545809,0.00001473588,0.0003585416,0.00003498737,0.00008134731,0.9891734,0.0002656368,0.001377146,0.006303231],"study_design_scores_gemma":[0.0002640183,0.002608277,0.07274388,0.00004807102,0.00009463882,0.003868768,0.0003704242,0.002980522,0.8955253,0.0005562266,0.02091798,0.00002191458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989405,0.002652402,0.001786819,0.0005793914,0.0001077668,0.00005410773,0.001330577,0.000282176,0.003801645],"genre_scores_gemma":[0.994186,0.0007877535,0.0006028061,0.0002011373,0.00001381259,0.00003032998,0.0007452534,0.00002912778,0.003403643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003032877,"threshold_uncertainty_score":0.01014596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04211925821515174,"score_gpt":0.3829273282088889,"score_spread":0.3408080699937372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}