{"id":"W4414465163","doi":"10.1158/2326-6074.cimm25-a004","title":"Abstract A004: Modulating chromatin remodeling as a strategy to reverse immune evasion in ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Immune system; Chromatin remodeling; Antigen presentation; Immunotherapy; Chromatin; Immunogenicity; Ovarian cancer; Immune checkpoint; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001120465,0.0002559376,0.0006011943,0.0008401695,0.0002631378,0.00005416281,0.0002849802,0.0002894925,0.001380839],"category_scores_gemma":[0.0003096067,0.0002374823,0.0001107649,0.001477603,0.000153535,0.0001219035,0.0002401435,0.001053465,0.0001302961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002217153,"about_ca_system_score_gemma":0.002174556,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04076429,"about_ca_topic_score_gemma":0.002044579,"domain_scores_codex":[0.9970659,0.0001929654,0.0006290274,0.0007581853,0.0004314946,0.0009224236],"domain_scores_gemma":[0.9983481,0.0002412574,0.00008296857,0.0007454722,0.0004431762,0.0001390487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003218609,0.0009488717,0.04861981,0.0006389121,0.001062981,0.0005266978,0.00185095,0.007169139,0.5093803,0.002284851,0.004573344,0.4197255],"study_design_scores_gemma":[0.009543951,0.001001464,0.9134787,0.00761502,0.0001215344,0.00002923148,0.001800242,0.00195319,0.0540028,0.001769795,0.008218539,0.0004655198],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477167,0.02009227,0.00002687453,0.02062724,0.0004699198,0.001544057,0.00002095298,0.00005154136,0.009450459],"genre_scores_gemma":[0.9912883,0.003971721,0.0003772929,0.0006723236,0.0001448792,0.001387666,0.0000188218,0.00003893589,0.002100082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8648589,"threshold_uncertainty_score":0.999532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09923062220342622,"score_gpt":0.4569732006418941,"score_spread":0.3577425784384679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}