{"id":"W4414465167","doi":"10.1158/2326-6074.cimm25-b022","title":"Abstract B022: Investigating Biased GPCRs Activation by Nutraceutical Caffeine and Nicotine in Transactivating Glycosylated Receptors to Induce EMT in Cancer Metastasis","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"G protein-coupled receptor; Receptor; Cancer cell; Signal transduction; Inflammation; Caffeine; Cell signaling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023713,0.0002726985,0.0003429057,0.0001750101,0.0001918713,0.0002254656,0.0001945102,0.0003742442,0.002468354],"category_scores_gemma":[0.0001058171,0.0001104228,0.0005493473,0.0001707731,0.0001313559,0.0002113861,0.0001484848,0.0005141091,0.0006218288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002595574,"about_ca_system_score_gemma":0.0002489319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159916,"about_ca_topic_score_gemma":0.001731929,"domain_scores_codex":[0.9998578,0.00002495826,0.00001104426,0.00002891183,0.00004042861,0.00003681173],"domain_scores_gemma":[0.9999442,0.000008416812,0.00001160377,0.000005900353,0.00001448889,0.00001537611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003473427,0.0001148461,0.0001798668,0.0001048354,0.000009846533,0.0000351203,0.00001160878,0.00004872154,0.9976889,0.00007307577,0.0000909302,0.001295009],"study_design_scores_gemma":[0.00005413943,0.002231611,0.006336815,0.000015387,0.00005970059,0.0001249783,0.00005138842,0.001014285,0.98581,0.00005657861,0.004234878,0.00001012866],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9900013,0.003433772,0.002703961,0.0002460458,0.0001007297,0.000154324,0.0009737805,0.00005439025,0.002331585],"genre_scores_gemma":[0.9862175,0.002543529,0.003411019,0.0002185712,0.00003284675,0.0002132481,0.001093806,0.00002986014,0.006239759],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002468354,"threshold_uncertainty_score":0.008257449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09163168663077802,"score_gpt":0.4273441446349585,"score_spread":0.3357124580041805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}