{"id":"W4414465167","doi":"10.1158/2326-6074.cimm25-b022","title":"Abstract B022: Investigating Biased GPCRs Activation by Nutraceutical Caffeine and Nicotine in Transactivating Glycosylated Receptors to Induce EMT in Cancer Metastasis","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"G protein-coupled receptor; Receptor; Cancer cell; Signal transduction; Inflammation; Caffeine; Cell signaling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001585375,0.0002998702,0.0007230395,0.00135612,0.0001967909,0.00004841909,0.0002406586,0.0003941901,0.0002799029],"category_scores_gemma":[0.001551001,0.0002976735,0.000063433,0.002852085,0.000510286,0.0002100842,0.00008355753,0.001900794,0.000005014886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001319483,"about_ca_system_score_gemma":0.001339804,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01756922,"about_ca_topic_score_gemma":0.002067919,"domain_scores_codex":[0.9966551,0.0005546623,0.0007080837,0.0007202883,0.0004076946,0.0009541703],"domain_scores_gemma":[0.9979364,0.001133174,0.0001026071,0.000382593,0.0002757237,0.0001695426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004149499,0.0002924295,0.04716129,0.000307773,0.0001945688,0.00001576059,0.001711142,0.00009666006,0.7603873,0.00002017988,0.001088185,0.1845752],"study_design_scores_gemma":[0.006013509,0.0004726908,0.3533185,0.003518931,0.00004686046,0.00001164743,0.002740795,0.0003366893,0.6226823,0.00004809714,0.01043528,0.0003747131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702035,0.01176162,0.00001602812,0.01646253,0.0001877608,0.001110718,0.00002052963,0.00004519719,0.0001921567],"genre_scores_gemma":[0.9944837,0.003457156,0.0001092477,0.0004887433,0.00007730858,0.0007189119,0.00003274661,0.00004443311,0.0005877732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3061572,"threshold_uncertainty_score":0.9999475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09163168663077802,"score_gpt":0.4273441446349585,"score_spread":0.3357124580041805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}