{"id":"W4414465317","doi":"10.1158/2326-6074.cimm25-pr-13","title":"Abstract PR-13: Myeloid checkpoint blockade potentiates radiotherapy by modulating dendritic cells and reducing Treg-driven immunosuppression","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Radioresistance; Immunotherapy; Blockade; Tumor microenvironment; Immune checkpoint; Immune system; Immunogenic cell death; Myeloid; Radiation therapy; Dendritic cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001103727,0.000465289,0.000737123,0.000613215,0.001175642,0.0001094989,0.0009395853,0.0009002955,0.001642634],"category_scores_gemma":[0.0001768083,0.0004507092,0.0001609774,0.0006172255,0.001952866,0.0002316168,0.0006272138,0.002408041,0.0001137717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006282749,"about_ca_system_score_gemma":0.000473648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002095882,"about_ca_topic_score_gemma":0.00002791168,"domain_scores_codex":[0.9955733,0.0008068717,0.000811965,0.001080865,0.0001568393,0.001570202],"domain_scores_gemma":[0.9976464,0.0007660063,0.0002143999,0.0009652948,0.0003603527,0.00004756193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004911013,0.0001530816,0.001499425,0.0001561391,0.0008631477,0.00001123148,0.0008536193,0.0001253834,0.9511738,0.0000435156,0.01000891,0.03462067],"study_design_scores_gemma":[0.003036722,0.0001769336,0.01020377,0.0007583197,0.00005222657,0.00004223609,0.0008104488,0.0001330635,0.9547252,0.0001961278,0.02944932,0.0004156019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7338471,0.2601199,0.00009371118,0.001589515,0.002349747,0.0006893148,0.00006080321,0.0001230326,0.00112678],"genre_scores_gemma":[0.9617642,0.02287805,0.0002045204,0.0001182508,0.00008234497,0.0003795387,0.00009119189,0.00007827237,0.01440367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2372419,"threshold_uncertainty_score":0.9998934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175557230761584,"score_gpt":0.3317457368542996,"score_spread":0.3099901645466838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}